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Rok 2024
Rok 2023
Rok 2022
  • Efficacy of intralesional bleomycin in treatment resistant viral warts
    Publikacja
    • M. Sławińska
    • J. Żółkiewicz
    • K. Pastuszak
    • K. Zawadzka
    • M. Sikorska
    • R. Nowicki
    • M. Sobjanek

    - Przegląd Dermatologiczny - Rok 2022

    Introduction Optimal management of treatment-refractory viral warts caused by human papillomavirus is unknown. One of the treatment methods is intralesional bleomycin solution. Objective To determine risk factors for resistant viral warts (not responding to conventional treatments for ≥ 6 months), to determine the effectiveness and safety of intralesional bleomycin in a group of patients with viral warts resistant to conventional...

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  • Significance of Dermoscopy in Association with Clinical Features in Differentiation of Basal Cell Carcinoma and Benign Trichoblastic Tumours
    Publikacja
    • M. Sławińska
    • A. Płaszczyńska
    • J. Lakomy
    • K. Pastuszak
    • W. Biernat
    • M. Sikorska
    • R. J. Nowicki
    • M. Sobjanek

    - Cancers - Rok 2022

    Background: Although basal cell carcinoma (BCC) can, in the majority of cases, be diagnosed based on clinical and dermoscopic assessment, a potential overlap with benign adnexal skin tumours seems to exist, including trichoblastic tumours (TT). Methods: Retrospective analysis of clinical and dermoscopic features of benign TT and BCC cases was performed to develop a diagnostic algorithm with a potential utility in clinical practice....

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Rok 2021
  • Bortezomib induces methylation changes in neuroblastoma cells that appear to play a significant role in resistance development to this compound
    Publikacja
    • K. Łuczkowska
    • K. E. Sokołowska
    • O. Taryma-Leśniak
    • K. Pastuszak
    • A. Supernat
    • J. Bybjerg-Grauholm
    • L. L. Hansen
    • E. Paczkowska
    • T. K. Wojdacz
    • B. Machaliński

    - Scientific Reports - Rok 2021

    The anticancer activity of bortezomib (BTZ) has been increasingly studied in a number of indications and promising results for the use of this treatment have been shown in neuroblastoma. As BTZ treatment is usually administered in cycles, the development of resistance and side effects in patients undergoing therapy with BTZ remains a major challenge for the clinical usage of this compound. Common resistance development also means...

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  • Diagnostic Accuracy of Liquid Biopsy in Endometrial Cancer
    Publikacja
    • M. Łukasiewicz
    • K. Pastuszak
    • S. Łapińska-Szumczyk
    • R. Różański
    • S. I. ’. Veld
    • M. Bieńkowski
    • T. Stokowy
    • M. Ratajska
    • M. G. Best
    • T. Würdinger... i 3 innych

    - Cancers - Rok 2021

    Background: Liquid biopsy is a minimally invasive collection of a patient body fluid sample. In oncology, they offer several advantages compared to traditional tissue biopsies. However, the potential of this method in endometrial cancer (EC) remains poorly explored. We studied the utility of tumor educated platelets (TEPs) and circulating tumor DNA (ctDNA) for preoperative EC diagnosis, including histology determination. Methods:...

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  • Graphs hard-to-process for greedy algorithm MIN
    Publikacja

    We compare results of selected algorithms that approximate the independence number in terms of the quality of constructed solutions. Furthermore, we establish smallest hard- to-process graphs for the greedy algorithm MIN.

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  • imPlatelet classifier: image‐converted RNA biomarker profiles enable blood‐based cancer diagnostics
    Publikacja
    • K. Pastuszak
    • A. Supernat
    • M. G. Best
    • S. In ‘t Veld
    • S. Łapińska‐Szumczyk
    • A. Łojkowska
    • R. Różański
    • A. Żaczek
    • J. Jassem
    • T. Würdinger
    • T. Stokowy

    - Molecular Oncology - Rok 2021

    Liquid biopsies offer a minimally invasive sample collection, outperforming traditional biopsies employed for cancer evaluation. The widely used material is blood, which is the source of tumor-educated platelets. Here, we developed the imPlatelet classifier, which converts RNA-sequenced platelet data into images in which each pixel corresponds to the expression level of a certain gene. Biological knowledge from the Kyoto Encyclopedia...

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  • Interval Edge Coloring of Bipartite Graphs with Small Vertex Degrees

    An edge coloring of a graph G is called interval edge coloring if for each v ∈ V(G) the set of colors on edges incident to v forms an interval of integers. A graph G is interval colorable if there is an interval coloring of G. For an interval colorable graph G, by the interval chromatic index of G, denoted by χ'_i(G), we mean the smallest number k such that G is interval colorable with k colors. A bipartite graph G is called (α,β)-biregular...

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  • Modelling of dark fermentation of glucose and sour cabbage
    Publikacja

    In the article, modified Anaerobic Digestion Models 1 (ADM-1) was tested for modelling dark fermentation for hydrogen production. The model refitting was done with the Euler method. The new model was based on sets of differential equations. The model was checked for hydrogen production from sour cabbage in batch and semi-batch in 5 g VSS (volatile solid suspension)/L and at the semi-batch process from glucose at 5 and 10 g VSS/L....

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  • Sztuczna inteligencja w onkologii - nowe narzędzia do diagnostyki i medycyny spersonalizowanej
    Publikacja

    - Rok 2021

    statnie dekady doprowadziły do rozwoju zaawansowanych technologii badawczych, cechujących się wysoką przepustowością. Zmienia to oblicze medycyny, doprowadzając do generowania ogromnej ilości danych. Z każdym kolejnym rokiem przybywa pacjentów onkologicznych, a zebrane informacje o pacjentach przekraczają możliwości lekarzy i naukowców w zakresie samodzielnej analizy tzw. big data. Właśnie dlatego świat nauki coraz częściej zwraca...

  • Towards Cancer Patients Classification Using Liquid Biopsy

    Liquid biopsy is a useful, minimally invasive diagnostic and monitoring tool for cancer disease. Yet, developing accurate methods, given the potentially large number of input features, and usually small datasets size remains very challenging. Recently, a novel feature parameterization based on the RNA-sequenced platelet data which uses the biological knowledge from the Kyoto Encyclopedia of Genes and Genomes, combined with a classifier...

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  • Transcriptomic landscape of blood platelets in healthy donors
    Publikacja
    • A. Supernat
    • M. Popęda
    • K. Pastuszak
    • M. G. Best
    • P. Grešner
    • S. I. ’. Veld
    • B. Siek
    • N. Bednarz-Knoll
    • M. T. Rondina
    • T. Stokowy... i 3 innych

    - Scientific Reports - Rok 2021

    Blood platelet RNA-sequencing is increasingly used among the scientific community. Aberrant platelet transcriptome is common in cancer or cardiovascular disease, but reference data on platelet RNA content in healthy individuals are scarce and merit complex investigation. We sought to explore the dynamics of platelet transcriptome. Datasets from 204 healthy donors were used for the analysis of splice variants, particularly with...

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  • Transcriptomic landscape of blood platelets in healthy donors
    Publikacja
    • A. Supernat
    • M. Popęda
    • K. Pastuszak
    • M. G. Best
    • P. Gresner
    • S. In ‘t Veld
    • B. Siek
    • N. Bednarz-Knoll
    • M. T. Rondina
    • T. Stokowy... i 3 innych

    - Scientific Reports - Rok 2021

    BACKGROUND Blood platelet RNA-sequencing is increasingly used among the scientific community. Aberrant platelet transcriptome is common in cancer or cardiovascular disease, but reference data on platelet RNA content in healthy individuals are scarce and merit complex investigation. METHODS We sought to explore the dynamics of platelet transcriptome. Datasets from 204 healthy donors were used for the analysis of splice variants,...

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Rok 2017
  • No-Wait & No-Idle Open Shop Minimum Makespan Scheduling with Bioperational Jobs

    In the open shop scheduling with bioperational jobs each job consists of two unit operations with a delay between the end of the first operation and the beginning of the second one. No-wait requirement enforces that the delay between operations is equal to 0. No-idle means that there is no idle time on any machine. We model this problem by the interval incidentor (1, 1)-coloring (IIR(1, 1)-coloring) of a graph with the minimum...

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