Rok 2023

• Microemulsion Delivery Systems with Low Surfactant Concentrations: Optimization of Structure and Properties by Glycol Cosurfactants

  Publikacja

  • P. Szumała
  • S. Mania
  • B. Makurat-Kasprolewicz
  • J. Kaplińska

  - MOLECULAR PHARMACEUTICS - Rok 2023

  Extensive use of microemulsions as delivery systems raises interest in the safe ingredients that can form such systems. Here, we assessed the use of two glycols, i.e., propylene glycol and pentylene glycol, and their mixtures to manipulate the properties and structure of microemulsions. Obtained systems with glycols were extensively characterized in terms of capacity to incorporate water phase, droplet size, polydispersity, structure...

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Rok 2021

• Encapsulation of Amikacin into Microparticles Based on Low-Molecular-Weight Poly(lactic acid) and Poly(lactic acid-co-polyethylene glycol)

  Publikacja

  • M. Glinka
  • K. Filatova
  • J. Kucińska-Lipka
  • E. D. Bergerova
  • A. Wasik
  • V. Sedlařík

  - MOLECULAR PHARMACEUTICS - Rok 2021

  The aim of this study was to fabricate novel microparticles (MPs) for efficient and long-term delivery of amikacin (AMI). The emulsification method proposed for encapsulating AMI employed low-molecular-weight poly(lactic acid) (PLA) and poly(lactic acid-co-polyethylene glycol) (PLA−PEG), both supplemented with poly(vinyl alcohol) (PVA). The diameters of the particles obtained were determined as less than 30 μm. Based on an in-vitro...

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Rok 2018

• Mechanism of Binding of Antifungal Antibiotic Amphotericin B to Lipid Membranes: An Insight from Combined Single-Membrane Imaging, Microspectroscopy, and Molecular Dynamics

  Publikacja

  • E. Grela
  • M. Wieczór
  • R. Luchowski
  • J. Zielinska
  • A. Barzycka
  • W. Grudzinski
  • K. Nowak
  • P. Tarkowski
  • J. Czub
  • W. Gruszecki

  - MOLECULAR PHARMACEUTICS - Rok 2018

  Amphotericin B is a lifesaving polyene antibiotic used in the treatment of systemic mycoses. Unfortunately, the pharmacological applicability of this drug is limited because of its severe toxic side effects. At the same time, the lack of a well-defined mechanism of selectivity hampers the efforts to rationally design safer derivatives. As the drug primarily targets the biomembranes of both fungi and humans, new insights into the...

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Rok 2015

• Structural Characterization and in Vivo Evaluation of β-Hairpin Peptidomimetics as Specific CXCR4 Imaging Agents

  Publikacja

  • W. Lesniak
  • E. Sikorska
  • H. Shallal
  • B. Behnam
  • A. Lisok
  • M. Pullambhatla
  • M. Pomper
  • S. Nimmagadda

  - MOLECULAR PHARMACEUTICS - Rok 2015

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Rok 2013

• 99mTc-Galacto-RGD2: A Novel 99mTc-Labeled Cyclic RGD Peptide Dimer Useful for Tumor Imaging

  Publikacja

  • S. Ji
  • A. Czerwiński
  • Y. Zhou
  • G. Shao
  • F. Valenzuela
  • P. Sowiński
  • S. Chauhan
  • M. Pennington
  • S. Liu

  - MOLECULAR PHARMACEUTICS - Rok 2013

  This study sought to evaluate [99mTc(HYNIC-Galacto-RGD2)-(tricine)(TPPTS)] (99mTc-Galacto-RGD2: HYNIC = 6-hydrazinonicotinyl; Galacto-RGD2 = Glu[cyclo[Arg-Gly-Asp-D-Phe-Lys(SAA-PEG2-(1,2,3-triazole)-1-yl-4-ethylamide)]]2 (SAA = 7-amino-L-glycero-L-galacto-2,6-anhydro-7-eoxyheptanamide, and PEG2 = 3,6-dioxaoctanoic acid); and TPPTS = trisodium triphenylphosphine-3,3',3''-trisulfonate) as a new radiotracer for tumor imaging. Galacto-RGD2...

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Rok 2011

• Reversed-Phase TLC and HPLC Retention Data in Correlation Studies with in Silico Molecular Descriptors and Druglikeness Properties of Newly Synthesized Anticonvulsant Succinimide Derivatives

  Publikacja

  • N. Perisic-Janjic
  • R. Kaliszan
  • P. Wiczling
  • N. Milosevic
  • G. Uscumlic
  • N. Banjac

  - MOLECULAR PHARMACEUTICS - Rok 2011

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