Paweł Sachadyn - Publikacje - MOST Wiedzy

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Zdjęcie profilowe: prof. dr hab. inż. Paweł Sachadyn

prof. dr hab. inż. Paweł Sachadyn

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wszystkich: 51

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Katalog Publikacji

Rok 2024
  • CHEMOTHERAPY-MEDIATED COMPLICATIONS OF WOUND HEALING. AN UNDERSTUDIED SIDE EFFECT
    Publikacja

    - Advances in Wound Care - Rok 2024

    Significance: Chemotherapy is a primary method to treat cancer, but while cytotoxic drugs are designed to target rapidly dividing cancer cells, they can also affect other cell types, including dermal cells and macrophages involved in wound healing, which often leads to the development of chronic wounds. The situation becomes even more severe when chemotherapy is combined with surgical tumor excision. Recent advances: Despite its...

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Rok 2023
Rok 2022
Rok 2021
  • Functionalized Peptide Fibrils as a Scaffold for Active Substances in Wound Healing
    Publikacja
    • J. Sawicka
    • E. Iłowska
    • M. Deptuła
    • P. Sosnowski
    • P. Sass
    • K. Czerwiec
    • K. Chmielewska
    • A. Szymańska
    • Z. Pietralik-Molińska
    • M. Kozak... i 3 innych

    - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - Rok 2021

    Technological developments in the field of biologically active peptide applications in medicine have increased the need for new methods for peptide delivery. The disadvantage of peptides as drugs is their low biological stability. Recently, great attention has been paid to self-assembling peptides that can form fibrils. Such a formulation makes bioactive peptides more resistant to enzymatic degradation and druggable. Peptide fibrils...

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  • PTD4 Peptide Increases Neural Viability in an In Vitro Model of Acute Ischemic Stroke
    Publikacja
    • J. Mazuryk
    • I. Puchalska
    • K. Koziński
    • M. J. Ślusarz
    • J. Ruczyński
    • P. Rekowski
    • P. Rogujski
    • R. Płatek
    • M. B. Wiśniewska
    • A. Piotrowski... i 7 innych

    - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - Rok 2021

    Ischemic stroke is a disturbance in cerebral blood flow caused by brain tissue ischemia and hypoxia. We optimized a multifactorial in vitro model of acute ischemic stroke using rat primary neural cultures. This model was exploited to investigate the pro-viable activity of cell-penetrating peptides: arginine-rich Tat(49–57)-NH2 (R49KKRRQRRR57-amide) and its less basic analogue, PTD4 (Y47ARAAARQARA57-amide). Our model included glucose...

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Rok 2020
Rok 2019
Rok 2018
Rok 2017
Rok 2016
Rok 2015
Rok 2014
  • Conserved motifs of MutL proteins

    tThe MutL protein is best known for its function in DNA mismatch repair (MMR). However, there isevidence to suggest that MutL is not only the linker connecting the functions of MutS and MutH in MMR,but that it also participates in other repair systems, such as Very Short Patch (VSP), Base Excision (BER)and Nucleotide Excision Repair (NER). This study set out to identify the most highly conserved aminoacid sequence motifs in MutL...

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Rok 2013
Rok 2012
Rok 2011
  • Cardinal regenerative features of the MRL mouse
    Publikacja

    - Gene Therapy and Regulation - Rok 2011

    In this review, we discuss recent studies relating to major features of adult MRL mouse biology that contribute to the regenerative responses seen. These include an increased inflammatory cell profile, a unique glycolytic metabolic state typically found during embryogenesis, and a cell cycle phenotype of DNA damage and G2/M arrest. These traits have been found in other mammalian and non-mammalian regenerative systems. How these...

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  • CARDINAL REGENERATIVE FEATURES OF THE MRL MOUSE — AN UPDATE
    Publikacja
    • L. ARTHUR
    • P. SACHADYN
    • D. GOUREVITCH
    • E. HEBER-KATZ
    • P. Sachadyn

    - Gene Therapy and Regulation - Rok 2011

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Rok 2010
  • Conservation and diversity of MutS proteins

    The homologues of MutS, mismatch repair protein, exist in all prokaryotes, with the exception of Actinobacteria, Mollicutes and part of the Archaea. Multiple alignments of 316 MutS amino acid sequences from 169 species revealed conserved residues and sequence motifs distinguishing MutS homologues. All MutS homologues show high conservation within the ATPase domain. MutS1, the homologue responsible for DNA mismatch recognition,...

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Rok 2009
  • A cryptic ribosome binding site, false signals in reporter systems and avoidance of protein translation chaos
    Publikacja

    - JOURNAL OF BIOTECHNOLOGY - Rok 2009

    The expression of reporter gene may be induced by activation of cryptic signalling sequences, as we found while constructing the mutS-lacZ fusion gene. We cloned the Escherichia coli lacZ gene encoding beta-galactosidase into a plasmid vector carrying the Thermus thermophilus mutS gene. The clones expected to produce beta-galactosidase as the C-terminal fusion were selected for the complementation of beta-galactosidase activity...

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  • Retained features of embryonic metabolism in the adult MRL mouse
    Publikacja
    • R. K. Naviaux
    • T. H. Le
    • K. Bedelbaeva
    • J. Leferovich
    • D. Gourevitch
    • P. Sachadyn
    • X. Zhang
    • C. Lise
    • H. Ellen

    - MOLECULAR GENETICS AND METABOLISM - Rok 2009

    The MRL mouse is an inbred laboratory strain that was derived by selective breeding in 1960 from the rapidly growing LG/J (Large) strain. MRL mice grow to nearly twice the size of other commonly used mouse strains, display uncommonly robust healing and regeneration properties, and express later onset autoimmune traits similar to Systemic Lupus Erythematosis. The regeneration trait (heal) in the MRL mouse maps to 14-20 quantitative...

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Rok 2008
  • Naturally occurring mitochondrial DNA heteroplasmy in the MRL mouse
    Publikacja
    • P. Sachadyn
    • X. Zhang
    • L. D. Clark
    • R. K. Naviaux
    • E. Heber-Katz

    - MITOCHONDRION - Rok 2008

    The MRL/MpJ mouse is an inbred laboratory strain of Mus musculus, known to exhibit enhanced autoimmunity, increased wound healing, and increased regeneration properties. We report the full-length mitochondrial DNA (mtDNA) sequence of the MRL mouse (Accession # EU450583), and characterize the discovery of two naturally occurring heteroplasmic sites. The first is a T3900C substitution in the TpsiCloop of the tRNA methionine gene...

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Rok 2007
Rok 2006
Rok 2005
Rok 2004
  • Functional domains of Candida albicans glucosamine-6-phosphate synthase.
    Publikacja

    Skonstruowano oddzielnie dwie domeny syntazy GlcN-6-P z Candida albicans jako białka fuzyjne, tj. domenę glutaminazową oraz domenę izomerazową, zawierające sekwencje poliHis, odpowiednio na C- i N-końcu. Zoptymalizowano warunki nadekspresji domen w komórkach Escherichia coli. Oba białka oczyszczono do homogenności przy zastosowaniu chromatografii metalopowinowactwa oraz zbadano ich podstawowe właściwości. Wyznaczono parametry kinetyczne...

Rok 2003
Rok 2000
Rok 1999
Rok 1998

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