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Customizing nano-chitosan for sustainable drug delivery

Abstrakt

Chitosan is a natural polymer with acceptable biocompatibility, biodegradability, and mechanical stability; hence, it has been widely appraised for drug and gene delivery applications. However, there has been no comprehensive assessment to tailor-make chitosan cross-linkers of various types and functionalities as well as complex chitosan-based semi- and full-interpenetrating networks for drug delivery systems (DDSs). Herein, various fabrication methods developed for chitosan hydrogels are deliberated, including chitosan crosslinking with and without diverse cross-linkers. Tripolyphosphate, genipin and multi-functional aldehydes, carboxylic acids, and epoxides are common cross-linkers used in developing biomedical chitosan for DDSs. Methods deployed for modifying the properties and performance of chitosan hydrogels, via their composite production (semi- and full-interpenetrating networks), are also cogitated here. In addition, recent advances in the fabrication of advanced chitosan hydrogels for drug delivery applications such as oral drug delivery, transdermal drug delivery, and cancer therapy are discussed. Lastly, thoughts on what is needed for the chitosan field to continue to grow is also debated in this comprehensive review article.

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Kategoria:
Publikacja w czasopiśmie
Typ:
artykuły w czasopismach
Opublikowano w:
JOURNAL OF CONTROLLED RELEASE nr 350, strony 175 - 192,
ISSN: 0168-3659
Język:
angielski
Rok wydania:
2022
Opis bibliograficzny:
Saeedi M., Vahidi O., Moghbeli M. R., Ahmadi S., Asadnia M., Akhavan O., Seidi F., Rabiee M., Saeb M., Webster T. J., Varma R. S., Sharifi E., Zarrabi A., Rabiee N.: Customizing nano-chitosan for sustainable drug delivery// JOURNAL OF CONTROLLED RELEASE -Vol. 350, (2022), s.175-192
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1016/j.jconrel.2022.07.038
Źródła finansowania:
  • COST_FREE
Weryfikacja:
Politechnika Gdańska

wyświetlono 49 razy

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