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Distinct hippocampal-prefrontal neural assemblies coordinate memory encoding, maintenance, and recall

Abstrakt

Short-term memory enables incorporation of recent experience into subsequent decision-making. This processing recruits both the prefrontal cortex and hippocampus, where neurons encode task cues, rules, and outcomes. However, precisely which information is carried when, and by which neurons, remains unclear. Using population decoding of activity in rat medial prefrontal cortex (mPFC) and dorsal hippocampal CA1, we confirm that mPFC populations lead in maintaining sample information across delays of an operant nonmatch to sample task, despite individual neurons firing only transiently. During sample encoding, distinct mPFC subpopulations joined distributed CA1-mPFC cell assemblies hallmarked by 4–5 Hz rhythmic modulation; CA1-mPFC assemblies re-emerged during choice episodes but were not 4–5 Hz modulated. Delay-dependent errors arose when attenuated rhythmic assembly activity heralded collapse of sustained mPFC encoding. Our results map component processes of memory-guided decisions onto heterogeneous CA1-mPFC subpopulations and the dynamics of physiologically distinct, distributed cell assemblies.

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Wersja publikacji
Accepted albo Published Version
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1016/j.cub.2023.02.029
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Creative Commons: CC-BY otwiera się w nowej karcie

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Informacje szczegółowe

Kategoria:
Publikacja w czasopiśmie
Typ:
artykuły w czasopismach
Opublikowano w:
CURRENT BIOLOGY nr 33, strony 1220 - 1236,
ISSN: 0960-9822
Język:
angielski
Rok wydania:
2023
Opis bibliograficzny:
Domanski A., Kucewicz M., Russo E., Tricklebank M. D., Robinson J. E., Durstewitz D., Jones M. W.: Distinct hippocampal-prefrontal neural assemblies coordinate memory encoding, maintenance, and recall// CURRENT BIOLOGY -Vol. 33,iss. 7 (2023), s.1220-1236
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1016/j.cub.2023.02.029
Źródła finansowania:
  • Wellcome Trust UK
  • Medical Research Council UK
Weryfikacja:
Politechnika Gdańska

wyświetlono 91 razy

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