Recent progress in the development of steroid sulfatase inhibitors – examples of the novel and most promising compounds from the last decade - Publikacja - MOST Wiedzy

Twoje konto

zaloguj

Wyszukiwarka

Recent progress in the development of steroid sulfatase inhibitors – examples of the novel and most promising compounds from the last decade

Abstrakt

The purpose of this review article is to provide an overview of recent achievements in the synthesis of novel steroid sulfatase (STS) inhibitors. STS is a crucial enzyme in the biosynthesis of active hormones (including estrogens and androgens) and, therefore, represents an extremely attractive molecular target for the development of hormone-dependent cancer therapies. The inhibition of STS may effectively reduce the availability of active hormones for cancer cells, causing a positive therapeutic effect. Herein, we report examples of novel STS inhibitors based on steroidal and nonsteroidal cores that contain various functional groups (e.g., sulfamate and phosphorus moieties) and halogen atoms, which may potentially be used in therapies for hormone-dependent cancers. The presented work also includes examples of multitargeting agents with STS inhibitory activities. Furthermore, the fundamental discoveries in the development of the most promising drug candidates exhibiting STS inhibitory activities are highlighted.

Cytowania

  • 1 5

    CrossRef

  • 0

    Web of Science

  • 1 3

    Scopus

Autorzy (7)

Cytuj jako

Pełna treść

pobierz publikację
pobrano 89 razy
Wersja publikacji
Accepted albo Published Version
Licencja
Creative Commons: CC-BY otwiera się w nowej karcie

Słowa kluczowe

Informacje szczegółowe

Kategoria:
Publikacja w czasopiśmie
Typ:
artykuły w czasopismach
Opublikowano w:
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY nr 35, strony 1163 - 1184,
ISSN: 1475-6366
Język:
angielski
Rok wydania:
2020
Opis bibliograficzny:
Daśko M., Demkowicz S., Biernacki K., Ciupak O., Kozak W., Masłyk M., Rachoń J.: Recent progress in the development of steroid sulfatase inhibitors – examples of the novel and most promising compounds from the last decade// JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY -Vol. 35,iss. 1 (2020), s.1163-1184
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1080/14756366.2020.1758692
Źródła finansowania:
Weryfikacja:
Politechnika Gdańska

wyświetlono 224 razy

Publikacje, które mogą cię zainteresować

Synthesis and biological evaluation of N-acylated tyramine sulfamates containing C-F bonds as steroid sulfatase inhibitors

2017

New potent STS inhibitors based on fluorinated 4-(1-phenyl-1H-[1,2,3]triazol-4-yl)-phenyl sulfamates

2019

Novel steroid sulfatase inhibitors based on N ‐thiophosphorylated 3‐(4‐aminophenyl)‐coumarin‐7‐O‐sulfamates

2019

Synthesis and biological evaluation of fluorinated 3-phenylcoumarin-7-O-sulfamate derivatives as steroid sulfatase inhibitors

2016
Meta Tagi