The Influence of Calcium Glycerophosphate (GPCa) Modifier on Physicochemical, Mechanical, and Biological Performance of Polyurethanes Applicable as Biomaterials for Bone Tissue Scaffolds Fabrication - Publikacja - MOST Wiedzy

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The Influence of Calcium Glycerophosphate (GPCa) Modifier on Physicochemical, Mechanical, and Biological Performance of Polyurethanes Applicable as Biomaterials for Bone Tissue Scaffolds Fabrication

Abstrakt

In this paper we describe the synthesis of poly(ester ether urethane)s (PEEURs) by using selected raw materials to reach a biocompatible polyurethane (PU) for biomedical applications. PEEURs were synthesized by using aliphatic 1,6-hexamethylene diisocyanate (HDI), poly(ethylene glycol) (PEG), α,ω-dihydroxy(ethylene-butylene adipate) (Polios), 1,4-butanediol (BDO) as a chain extender and calcium glycerolphosphate salt (GPCa) as a modifier used to stimulate bone tissue regeneration. The obtained unmodified (PURs) and modified with GPCa (PURs-M) PEEURs were studied by various techniques. It was confirmed that urethane prepolymer reacts with GPCa modifier. Further analysis of the obtained PURs and PURs-M by Fourier transform infrared (FTIR) and Raman spectroscopy revealed the chemical composition typical for PUs by the confirmed presence of urethane bonds. Moreover, the FTIR and Raman spectra indicated that GPCa was incorporated into the main PU chain at least at one-side. The scanning electron microscopy (SEM) analysis of the PURs-M surface was in good agreement with the FTIR and Raman analysis due to the fact that inclusions were observed only at 20% of its surface, which were related to the non-reacted GPCa enclosed in the PUR matrix as filler. Further studies of hydrophilicity, mechanical properties, biocompatibility, short term-interactions, and calcification study lead to the final conclusion that the obtained PURs-M may by suitable candidate material for further scaffold fabrication. Scaffolds were prepared by the solvent casting/particulate leaching technique (SC/PL) combined with thermally-induced phase separation (TIPS). Such porous scaffolds had satisfactory pore sizes (36–100 μm) and porosity (77–82%) so as to be considered as suitable templates for bone tissue regeneration.

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Kategoria:
Publikacja w czasopiśmie
Typ:
artykuł w czasopiśmie wyróżnionym w JCR
Opublikowano w:
Polymers nr 9, strony 1 - 21,
ISSN: 2073-4360
Język:
angielski
Rok wydania:
2017
Opis bibliograficzny:
Kucińska-Lipka J., Gubańska I., Kostrzewa M., Włodarczyk D., Karczewski J., Janik H.: The Influence of Calcium Glycerophosphate (GPCa) Modifier on Physicochemical, Mechanical, and Biological Performance of Polyurethanes Applicable as Biomaterials for Bone Tissue Scaffolds Fabrication// Polymers. -Vol. 9, nr. 8 (2017), s.1-21
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.3390/polym9080329
Bibliografia: test
  1. Kucinska-Lipka, J.; Gubanska, I.; Strankowski, M.; Cieśliński, H.; Filipowicz, N.; Janik, H. Synthesis and characterization of cycloaliphatic hydrophilic polyurethanes, modified with L-ascorbic acid, as materials for soft tissue regeneration. Mater. Sci. Eng. C 2017, 75, 671-681. [CrossRef] [PubMed] otwiera się w nowej karcie
  2. Kucinska-Lipka, J.; Gubanska, I.; Janik, H.; Sienkiewicz, M. Fabrication of polyurethane and polyurethane based composite fibres by the electrospinning technique for soft tissue engineering of cardiovascular system. Mater. Sci. Eng. C 2015, 46, 166-176. [CrossRef] [PubMed] otwiera się w nowej karcie
  3. Park, I.S.; Woo, T.G.; Jeon, W.Y.; Park, H.H.; Lee, M.H.; Bae, T.S.; Keong, W.S. Surface characteristics of titanium anodized in the four different types of electrolyte. Electrochim. Acta 2007, 53, 863-870. [CrossRef] otwiera się w nowej karcie
  4. Du, J.; Zou, Q.; Zuo, Y.; Li, Y. Cytocompatibility and osteogenesis evaluation of HA/GCPU composite as scaffolds for bone tissue engineering. Int. J. Surg. 2014, 12, 404-407. [CrossRef] [PubMed] otwiera się w nowej karcie
  5. Ryszkowska, J.L.; Auguścik, M.; Sheikh, A.; Boccaccini, A.R. Biodegradable polyurethane composite scaffolds containing Bioglass?? for bone tissue engineering. Compos. Sci. Technol. 2010, 70, 1894-1908. [CrossRef] otwiera się w nowej karcie
  6. Kucinska-Lipka, J.; Gubanska, I.; Janik, H.; Pokrywczynska, M.; Drewa, T. L-ascorbic acid modified poly(ester urethane)s as a suitable candidates for soft tissue engineering applications. React. Funct. Polym. 2015, 97, 105-115. [CrossRef] otwiera się w nowej karcie
  7. Rezwan, K.; Chen, Q.Z.; Blaker, J.J.; Boccaccini, A.R. Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering. Biomaterials 2006, 27, 3413-3431. [CrossRef] [PubMed] otwiera się w nowej karcie
  8. Janik, H.; Marzec, M. A review: Fabrication of porous polyurethane scaffolds. Mater. Sci. Eng. C 2015, 48, 586-591. [CrossRef] [PubMed] otwiera się w nowej karcie
  9. Kucinska-Lipka, J.; Gubanska, I.; Sienkiewicz, M. Thermal and mechanical properties of polyurethanes modified with L-ascorbic acid. J. Therm. Anal. Calorim. 2017, 127, 1631-1638. [CrossRef] otwiera się w nowej karcie
  10. Liu, H.; Zhang, L.; Shi, P.; Zou, Q.; Zuo, Y.; Li, Y. Hydroxyapatite/polyurethane scaffold incorporated with drug-loaded ethyl cellulose microspheres for bone regeneration. J. Biomed. Mater. Res. B 2010, 95, 36-46. [CrossRef] [PubMed] otwiera się w nowej karcie
  11. Tetteh, G.; Khan, A.S.; Delaine-Smith, R.M.; Reilly, G.C.; Rehman, I.U. Electrospun polyurethane/hydroxyapatite bioactive Scaffolds for bone tissue engineering: The role of solvent and hydroxyapatite particles. J. Mech. Behav. Biomed. Mater. 2014, 39, 95-110. [CrossRef] [PubMed] otwiera się w nowej karcie
  12. Dong, Z.; Li, Y.; Zou, Q. Degradation and biocompatibility of porous nano-hydroxyapatite/polyurethane composite scaffold for bone tissue engineering. Appl. Surf. Sci. 2009, 255, 6087-6091. [CrossRef] otwiera się w nowej karcie
  13. Laschke, M.W.; Strohe, A.; Menger, M.D.; Alini, M.; Eglin, D. In vitro and in vivo evaluation of a novel nanosize hydroxyapatite particles/poly(ester-urethane) composite scaffold for bone tissue engineering. Acta Biomater. 2010, 6, 2020-2027. [CrossRef] [PubMed] otwiera się w nowej karcie
  14. Bonzani, I.C.; Adhikari, R.; Houshyar, S.; Mayadunne, R.; Gunatillake, P.; Stevens, M.M. Synthesis of two-component injectable polyurethanes for bone tissue engineering. Biomaterials 2007, 28, 423-433. [CrossRef] [PubMed] otwiera się w nowej karcie
  15. Adhikari, R.; Gunatillake, P.A.; Griffiths, I.; Tatai, L.; Wickramaratna, M.; Houshyar, S.; Moore, T.; Mayadunne, R.T.M.; Mc Gee, M.; Carbone, T. Biodegradable injectable polyurethanes: Synthesis and evaluation for orthopaedic applications. Biomaterials 2008, 29, 3762-3770. [CrossRef] [PubMed] otwiera się w nowej karcie
  16. Gorna, K.; Gogolewski, S. Preparation, degradation, and calcification of biodegradable polyurethane foams for bone graft substitutes. J. Biomed. Mater. Res. A 2003, 67, 813-827. [CrossRef] [PubMed] otwiera się w nowej karcie
  17. Zawadzak, E.; Bil, M.; Ryszkowska, J.; Nazhat, S.N.; Cho, J.; Bretcanu, O.; Roethe, J.A.; Boccaccini, A.R. Polyurethane foams electrophoretically coated with carbon nanotubes for tissue engineering scaffolds. Biomed. Mater. 2009, 4, 15008. [CrossRef] [PubMed] otwiera się w nowej karcie
  18. Polish Ministry of Health. Polish Online System of Legal Acts. Available online: http://isap.sejm.gov.pl/ (accessed on 13 July 2016). otwiera się w nowej karcie
  19. American Food and Drug Administration. Available online: www.fda.gov (accessed on 13 July 2016). otwiera się w nowej karcie
  20. Zaze, A.C.S.F.; Dias, A.P.; Amaral, J.G.; Miyasaki, M.L.; Sassaki, K.T.; Delbem, A.C.B. In situ evaluation of low-fluoride toothpastes associated to calcium glycerophosphate on enamel remineralization. J. Dent. 2014, 42, 1621-1625. [CrossRef] [PubMed] otwiera się w nowej karcie
  21. Carvalho, T.S.; Bönecker, M.; Altenburger, M.J.; Buzalaf, M.A.R.; Sampaio, F.C.; Lussi, A. Fluoride varnishes containing calcium glycerophosphate: Fluoride uptake and the effect on in vitro enamel erosion. Clin. Oral Investig. 2015, 19, 1429-1436. [CrossRef] [PubMed] otwiera się w nowej karcie
  22. Douglas, T.E.L.; Pilarek, M.; Kalaszczyńska, I.; Senderek, I.; Skwarczyńska, A.; Cuijpers, V.M.J.I.; Modrzejewska, Z.; Lewandowska-Szumieł, M.; Dubruel, P. Enrichment of chitosan hydrogels with perfluorodecalin promotes gelation and stem cell vitality. Mater. Lett. 2014, 128, 79-84. [CrossRef] otwiera się w nowej karcie
  23. Kavanaugh, T.E.; Clark, A.Y.; Chan-Chan, L.H.; Ramírez-Saldaña, M.; Vargas-Coronado, R.F.; Cervantes-Uc, J.M. Human mesenchymal stem cell behavior on segmented polyurethanes prepared with biologically active chain extenders. J. Mater. Sci. Mater. Med. 2016, 27, 1-11. [CrossRef] [PubMed] Polymers 2017, 9, 329 20 of 21 otwiera się w nowej karcie
  24. Alves, P.; Coelho, J.F.J.; Haack, J.; Rota, A.; Bruinink, A.; Gil, M.H. Surface modification and characterization of thermoplastic polyurethane. Eur. Polym. J. 2009, 45, 1412-1419. [CrossRef] otwiera się w nowej karcie
  25. Boloori Zadeh, P.; Corbett, S.C.; Nayeb-Hashemi, H. In-vitro calcification study of polyurethane heart valves. Mater. Sci. Eng. C 2014, 35, 335-340. [CrossRef] [PubMed] otwiera się w nowej karcie
  26. Silvestri, A.; Boffito, M.; Sartori, S.; Ciardelli, G. Biomimetic materials and scaffolds for myocardial tissue regeneration. Macromol. Biosci. 2013, 13, 984-1019. [CrossRef] [PubMed] otwiera się w nowej karcie
  27. Courtney, T.; Sacks, M.S.; Stankus, J.; Guan, J.; Wagner, W.R. Design and analysis of tissue engineering scaffolds that mimic soft tissue mechanical anisotropy. Biomaterials 2006, 27, 3631-3638. [CrossRef] [PubMed] otwiera się w nowej karcie
  28. Karchin, A.; Simonovsky, F.I.; Ratner, B.D.; Sanders, J.E. Melt electrospinning of biodegradable polyurethane scaffolds. Acta Biomater. 2011, 7, 3277-3284. [CrossRef] [PubMed] otwiera się w nowej karcie
  29. Matsuda, T.; Ihara, M.; Inoguchi, H.; Kwon, I.K.; Takamizawa, K.; Kidoaki, S. Mechano-active scaffold design of small-diameter artificial graft made of electrospun segmented polyurethane fabrics. J. Biomed. Mater. Res. A 2005, 73, 125-131. [CrossRef] [PubMed] otwiera się w nowej karcie
  30. Coleman, M.M.; Lee, K.H.; Skrovanek, D.J.; Painter, P.C. Hydrogen bonding in polymers. 4. Infrared temperature studies of a simple polyurethane. Macromolecules 1986, 19, 2149-2157. [CrossRef] otwiera się w nowej karcie
  31. Coleman, M.M.; Skrovanek, D.J.; Hu, J.; Painter, P.C. Hydrogen bonding in polymer blends. 1. FTIR studies of urethane-ether blends. Macromolecules 1988, 21, 59-65. [CrossRef] otwiera się w nowej karcie
  32. Spirkova, M.; Poręba, R.; Pavlicevic, J.; Kobera, L.; Baldrian, J.; Pakarek, M. Aliphatic Polycarbonate-Based Polyurethane Elastomers and Nanocomposites. I. The Influence of Hard-Segment Content and Macrodiol-Constitution on Bottom-Up Self-Assembly. J. Appl. Polym. Sci. 2012, 126, 1016-1030. [CrossRef] otwiera się w nowej karcie
  33. Yilgor, I.; Yilgor, E.; Guler, I.G.; Ward, T.C.; Wilkes, G.L. FTIR investigation of the influence of diisocyanate symmetry on the morphology development in model segmented polyurethanes. Polymer 2006, 47, 4105-4114. [CrossRef] otwiera się w nowej karcie
  34. Yohannan Panicker, C.; Tresa Varghese, H.; Philip, D. FT-IR, FT-Raman and SERS spectra of Vitamin C. Spectrochim. Acta A 2006, 65, 802-804. [CrossRef] [PubMed] otwiera się w nowej karcie
  35. Asefnejad, A.; Khorasani, M.T.; Behnamghader, A.; Farsadzadeh, B.; Bonakdar, S. Manufacturing of biodegradable polyurethane scaffolds based on polycaprolactone using a phase separation method: Physical properties and in vitro assay. Int. J. Nanomed. 2011, 6, 2375-2384. [CrossRef] [PubMed] otwiera się w nowej karcie
  36. Xu, J.; Wu, T.; Peng, C.; Adegbite, S. Influence of acid and alkali pre-treatments on thermal degradation behaviour of polyisocyanurate foam and its carbon morphology. Polym. Degrad. Stab. 2017, 141, 104-118. [CrossRef] otwiera się w nowej karcie
  37. Cooke, S.L.; Whittington, A.R. Influence of therapeutic radiation on polycaprolactone and polyurethane biomaterials. Mater. Sci. Eng. C 2016, 60, 78-83. [CrossRef] [PubMed] otwiera się w nowej karcie
  38. Strankowski, M.; Włodarczyk, D.; Piszczyk, Ł.; Strankowska, J. Polyurethane Nanocomposites Containing Reduced Graphene Oxide, FTIR, Raman, and XRD Studies. J. Spectrosc. 2016, 2016. [CrossRef] otwiera się w nowej karcie
  39. Gough, J.E.; Notingher, I.; Hench, L.L. Osteoblast attachment and mineralized nodule formation on rough and smooth 45S5 bioactive glass monoliths. J. Biomed. Mater. Res. 2004, 68, 640-650. [CrossRef] [PubMed] otwiera się w nowej karcie
  40. Notingher, I.; Gough, J.E.; Hench, L.L. Study of osteoblasts mineralisation in-vitro by Raman micro-spectroscopy. Key Eng. Mater. 2004, 254-256, 769-772. [CrossRef] otwiera się w nowej karcie
  41. Silve, C.; Lopez, E.; Vidal, B.; Smith, D.C.; Camprasse, S.; Camprasse, G.; Couly, G. Nacre initiates biomineralization by human osteoblasts maintained In Vitro. Calcif. Tissue Int. 1992, 51, 363-369. [CrossRef] [PubMed] otwiera się w nowej karcie
  42. Barrioni, B.R.; De Carvalho, S.M.; Oréfice, R.L.; De Oliveira, A.A.R.; Pereira, M.D.M. Synthesis and characterization of biodegradable polyurethane films based on HDI with hydrolyzable crosslinked bonds and a homogeneous structure for biomedical applications. Mater. Sci. Eng. C 2015, 52, 22-30. [CrossRef] [PubMed] otwiera się w nowej karcie
  43. Gogolewski, S.; Gorna, K.; Turner, A.S. Regeneration of bicortical defects in the iliac crest of estrogen-deficient sheep, using new biodegradable polyurethane bone graft substitutes. J. Biomed. Mater. Res. 2006, 77, 802-810. [CrossRef] [PubMed] otwiera się w nowej karcie
  44. Amini, A.R.; Laurencin, C.T.; Nukavarapu, S.P. Bone Tissue Engineering: Recent Advances and Challenges. Crit. Rev. Biomed. Eng. 2012, 40, 363-408. [CrossRef] [PubMed] otwiera się w nowej karcie
  45. Henkel, J.; Woodruff, M.A.; Epari, D.R.; Steck, R.; Glatt, V.; Dickinson, I.C.; Choong, P.F.; Schuetz, M.A.; Hutmacher, D.W. Bone Regeneration Based on Tissue Engineering Conceptions-A 21st Century Perspective. Bone Res. 2013, 1, 216-248. [CrossRef] [PubMed] otwiera się w nowej karcie
  46. Yu, X.; Tang, X.; Gohil, S.V.; Laurencin, C.T. Biomaterials for Bone Regenerative Engineering. Adv. Healthc. Mater. 2015, 4, 1268-1285. [CrossRef] [PubMed] otwiera się w nowej karcie
  47. Bil, M.; Ryszkowska, J.; Woźniak, P.; Kurzydłowski, K.J.; Lewandowska-Szumieł, M. Optimization of the structure of polyurethanes for bone tissue engineering applications. Acta Biomater. 2010, 6, 2501-2510. [CrossRef] [PubMed] otwiera się w nowej karcie
  48. Guelcher, S.A.; Srinivasan, A.; Dumas, J.E.; Didier, J.E.; McBride, S.; Hollinger, J.O. Synthesis, mechanical properties, biocompatibility, and biodegradation of polyurethane networks from lysine polyisocyanates. Biomaterials 2008, 29, 1762-1775. [CrossRef] [PubMed] otwiera się w nowej karcie
  49. Chaudhury, M.K. Interfacial interaction between low energy surfaces. Mater. Sci. Eng. R Rep. 1996, 16, 97-159. [CrossRef] otwiera się w nowej karcie
  50. Król, P.; Król, B. Surface free energy of polyurethane coatings with improved hydrophobicity. Colloid Polym. Sci. 2012, 290, 879-893. [CrossRef] [PubMed] otwiera się w nowej karcie
  51. Sheikh, Z.; Najeeb, S.; Khurshid, Z.; Verma, V.; Rashid, H.; Glogauer, M. Biodegradable materials for bone repair and tissue engineering applications. Materials 2015, 8, 5744-5794. [CrossRef] otwiera się w nowej karcie
  52. Teoh, S.H.; Tang, Z.G.; Hastings, G.W. Chapter 3 Thermoplastic Polymers In Biomedical Applications: Structures, Properties and Processing. In Handbook of Biomaterial Properties; otwiera się w nowej karcie
  53. Murphy, W., Black, J., Hastings, G., Eds.; Springer: New York, NY, USA, 2016.
  54. Montini-Ballarin, F.; Caracciolo, P.C.; Rivero, G.; Abraham, G.A. In vitro degradation of electrospun poly(l-lactic acid)/segmented poly(ester urethane) blends. Polym. Degrad. Stab. 2016, 126, 159-169. [CrossRef] otwiera się w nowej karcie
  55. Gogolewski, S. Nonmetallic materials for bone substitutes. Eur. Cells Mater. 2001, 1 (Suppl. 2), 54-55. otwiera się w nowej karcie
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Politechnika Gdańska

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