Rok 2024

• Targeting shelterin proteins for cancer therapy.

  Publikacja

  • W. Brankiewicz-Kopcinska
  • A. Kallingal
  • R. Krzemieniecki
  • M. Bagiński

  - DRUG DISCOVERY TODAY - Rok 2024

  As a global health challenge, cancer prompts continuous exploration for innovative therapies that are also based on new targets. One promising avenue is targeting the shelterin protein complex, a safeguard for telomeres crucial in preventing DNA damage. The role of shelterin in modulating ataxia- telangiectasia mutated (ATM) and ataxia-telangiectasia and Rad3-related (ATR) kinases, key players in the DNA damage response (DDR),...

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• TRF1 and TRF2: pioneering targets in telomere-based cancer therapy

  Publikacja

  • A. Kallingal
  • R. Krzemieniecki
  • N. Maciejewska
  • W. Brankiewicz-Kopcinska
  • M. Bagiński

  - JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY - Rok 2024

  This article presents an in-depth exploration of the roles of Telomere Repeat-binding Factors 1 and 2 (TRF1 and TRF2), and the shelterin complex, in the context of cancer biology. It emphasizes their emerging significance as potential biomarkers and targets for therapeutic intervention. Central to the shelterin complex, TRF1 and TRF2 are crucial in maintaining telomere integrity and genomic stability, their dysregulation often...

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Rok 2023

• Mangiferin Affects Melanin Synthesis by an Influence on Tyrosinase: Inhibition, Mechanism of Action and Molecular Docking Studies

  Publikacja

  • A. Hering
  • J. Stefanowicz-Hajduk
  • S. Dziomba
  • R. Halasa
  • R. Krzemieniecki
  • S. Sappati
  • M. Bagiński (dawniej: M. Baginski)
  • R. J. Ochocka

  - Antioxidants - Rok 2023

  Mangiferin is a strong antioxidant that presents a wide range of biological activities. The aim of this study was to evaluate, for the first time, the influence of mangiferin on tyrosinase, an enzyme responsible for melanin synthesis and the unwanted browning process of food. The research included both the kinetics and molecular interactions between tyrosinase and mangiferin. The research proved that mangiferin inhibits tyrosinase...

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• Targeting Spike‐ACE2 Interface of SARS‐CoV‐2 and its Omicron Variant: A Comparative Screening of Potential Inhibitors for Existing and Anticipating Variants Using Molecular Modelling Approach

  Publikacja

  • D. Takkella
  • S. Sharma
  • R. Krzemieniecki
  • A. Pabbathi
  • S. Sappati
  • K. Gavvala

  - ChemistrySelect - Rok 2023

  The recent COVID pandemic has shown major impact on public health and economic crisis. Despite the development of many vaccines and drugs against the severe acute respiratory syndrome (SARS) coronavirus 2, the pandemic still persists. The continued spread of the virus is largely driven by the emergence of viral variants such as α, β, γ, delta, epsilon spike, omicron and its subvariants (BA.1,2,3) which can evade the current vaccines...

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