Rok 2023

• Mangiferin Affects Melanin Synthesis by an Influence on Tyrosinase: Inhibition, Mechanism of Action and Molecular Docking Studies

  Publikacja

  • A. Hering
  • J. Stefanowicz-Hajduk
  • S. Dziomba
  • R. Halasa
  • R. Krzemieniecki
  • S. Sappati
  • M. Bagiński (dawniej: M. Baginski)
  • R. J. Ochocka

  - Antioxidants - Rok 2023

  Mangiferin is a strong antioxidant that presents a wide range of biological activities. The aim of this study was to evaluate, for the first time, the influence of mangiferin on tyrosinase, an enzyme responsible for melanin synthesis and the unwanted browning process of food. The research included both the kinetics and molecular interactions between tyrosinase and mangiferin. The research proved that mangiferin inhibits tyrosinase...

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• Targeting Spike‐ACE2 Interface of SARS‐CoV‐2 and its Omicron Variant: A Comparative Screening of Potential Inhibitors for Existing and Anticipating Variants Using Molecular Modelling Approach

  Publikacja

  • D. Takkella
  • S. Sharma
  • R. Krzemieniecki
  • A. Pabbathi
  • S. Sappati
  • K. Gavvala

  - ChemistrySelect - Rok 2023

  The recent COVID pandemic has shown major impact on public health and economic crisis. Despite the development of many vaccines and drugs against the severe acute respiratory syndrome (SARS) coronavirus 2, the pandemic still persists. The continued spread of the virus is largely driven by the emergence of viral variants such as α, β, γ, delta, epsilon spike, omicron and its subvariants (BA.1,2,3) which can evade the current vaccines...

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