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• Butyrylcholinesterase signal sequence self-aggregates and enhances amyloid fibril formation in vitro

  Publikacja

  • J. Jasiecki
  • M. Targońska
  • A. Janaszak-Jasiecka
  • L. Kalinowski
  • K. Waleron
  • B. Wasąg

  - CHEMICO-BIOLOGICAL INTERACTIONS - Rok 2023

  Alzheimer’s disease (AD) pathogenesis has been attributed to extracellular aggregates of amyloid β (Aβ) plaques and neurofibrillary tangles in the human brain. It has been reported that butyrylcholinesterase (BChE) also accumulates in the brain Aβ plaques in AD. We have previously found that the BChE substitution in 5′UTR caused an in-frame N-terminal extension of 41 amino acids of the BChE signal peptide. The resultant variant...

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