Przeprowadzono wstępne badania in vivo of PTX opartego na lecytynie. Roztwór jest stabilny przez 24 godziny. Po podaniu królikom dawki 0,66mg/kg/h nie zanotowano zmian morfologicznych krwi w porównaniu do komercyjnego produktu Taxol.

The degradation of pentoxifylline (PTX) using H2O2, UV, H2O2/UV, Fenton and photo- Fenton processes has been examined in aqueous solution. The influence of various amount of oxidation agent on H2O2, H2O2/UV, Fenton and photo-Fenton reactions were investigated. Initial PTX concentration in Fenton and photo-Fenton was considerated. The addition of inorganic ions (Cl-, NO3-, SO42- and CO32-) on the degradation efficiency of PTX were...

Degradation of pentoxifylline (PTX) by sodium peroxydisulfate (SPDS) assisted by UV irradiation has been investigated in deionized water. The treatment was more favorable over direct photolysis or peroxydisulfate oxidation alone. The effects of various parameters, including different dosage of oxidant agent, PTX concentration, initial solution pH levels, and the presence of inorganic ions like chloride, nitrate and carbonate have...

The acridanone derivative 5-dimethylaminopropylamino- 8- hydroxytriazoloacridinone (C-1305) has been described as a potent inhibitor of cancer cell growth. Its mechanism of action in in vitro conditions was attributed, among others, to its ability to bind and stabilize the microtubule network and subsequently exhibit its tumour- suppressive effects in synergy with paclitaxel (PTX). Therefore, the objective of the present study...