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Wyniki wyszukiwania dla: dna sequence recognition

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Wyniki wyszukiwania dla: dna sequence recognition

  • DNA SEQUENCE

    Czasopisma

    ISSN: 1042-5179

  • Molecular Recognition in Complexes of TRF Proteins with Telomeric DNA

    Publikacja

    Telomeres are specialized nucleoprotein assemblies that protect the ends of linear chromosomes. In humans and many other species, telomeres consist of tandem TTAGGG repeats bound by a protein complex known as shelterin that remodels telomeric DNA into a protective loop structure and regulates telomere homeostasis. Shelterin recognizes telomeric repeats through its two major components known as Telomere Repeat-Binding Factors, TRF1...

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  • Interactions of telomeric proteins with nucleic acids: sequence recognition on intact and oxidatively damaged telomeres

    Publikacja

    - Rok 2019

    Telomeres are complex nucleoprotein assemblies that play a vital role in the maintenance of functional ends of linear chromosomes. Telomeric DNA, composed of tandem repeats of the 5'-TTAGGG-3' motif, solves the so-called end replication problem: as chromosomes shorten with each cell division, no information is lost, and the telomere can be re-extended. In the cell, many protein factors regulate telomere length, nuclear positioning...

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  • How proteins bind to DNA: target discrimination and dynamic sequence search by the telomeric protein TRF1

    Publikacja

    Target search as performed by DNA-binding proteins is a complex process, in which multiple factors contribute to both thermodynamic discrimination of the target sequence from overwhelmingly abundant off-target sites and kinetic acceleration of dynamic sequence interrogation. TRF1, the protein that binds to telomeric tandem repeats, faces an intriguing variant of the search problem where target sites are clustered within short fragments...

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  • Sequence-dependent structural properties of B-DNA: what have we learned in 40 years?

    Publikacja
    • G. da Rosa
    • L. Grille
    • V. Calzada
    • K. Ahmad
    • J. P. Arcon
    • F. Battistini
    • G. Bayarri
    • T. Bishop
    • P. Carloni
    • T. Cheatham III... i 16 innych

    - Biophysical Reviews - Rok 2021

    The structure of B-DNA, the physiological form of the DNA molecule, has been a central topic in biology, chemistry and physics. Far from uniform and rigid, the double helix was revealed as a flexible and structurally polymorphic molecule. Conformational changes that lead to local and global changes in the helix geometry are mediated by a complex choreography of base and backbone rearrangements affecting the ability of the B-DNA...

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