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Pre-analytical aspects in metabolomics of human biofluids – sample collection, handling, transport, and storage
Abstrakt
Metabolomics is the field of omics research that offers valuable insights into the complex composition of biological samples. It has found wide application in clinical diagnostics, disease investigation, therapy prediction, monitoring of treatment efficiency, drug discovery, or in-depth analysis of sample composition. A suitable study design constitutes the fundamental requirements to ensure robust and reliable results from the study data. The study design process should include a careful selection of conditions for each experimental step, from sample collection to data analysis. The pre-analytical variability that can introduce bias to the subsequent analytical process, decrease the outcome reliability, and confuse the final results of the metabolomics research, should also be considered. Herein, we provide key information regarding the pre-analytical variables affecting the metabolomics studies of biological fluids that are the most desirable type of biological samples. Our work offers a practical review that can serve and guide metabolomics pre-analytical design. It indicates pre-analytical factors, which can introduce artificial data variation and should be identified and understood during experimental design (through literature overview or analytical experiments).
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Informacje szczegółowe
- Kategoria:
- Publikacja w czasopiśmie
- Typ:
- artykuły w czasopismach
- Opublikowano w:
-
Molecular Omics
nr 19,
strony 95 - 104,
ISSN: 2515-4184 - Język:
- angielski
- Rok wydania:
- 2023
- Opis bibliograficzny:
- Garwolińska D., Kot-Wasik A., Hewelt-Belka W.: Pre-analytical aspects in metabolomics of human biofluids – sample collection, handling, transport, and storage// Molecular Omics -Vol. 19,iss. 2 (2023), s.95-104
- DOI:
- Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1039/d2mo00212d
- Źródła finansowania:
-
- Publikacja bezkosztowa
- Weryfikacja:
- Politechnika Gdańska
wyświetlono 98 razy
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