Year 2018

• Drug-drug interaction potential of antitumor acridine agent C-1748: The substrate of UDP-glucuronosyltransferases 2B7, 2B17 and the inhibitor of 1A9 and 2B7

  Publication

  • A. Mróz
  • I. Ryska
  • H. Sominka
  • A. Bejrowska
  • Z. Mazerska

  - Pharmacological Reports - Year 2018

  Background The compound 9-(2′-hydroxyethylamino)-4-methyl-1-nitroacridine (C-1748), the promising antitumor agent developed in our laboratory was determined to undergo phase I metabolic pathways. The present studies aimed to know its biotransformation with phase II enzymes – UDP-glucuronosyltransferases (UGTs) and its potential to be engaged in drug-drug interactions arising from the modulation of UGT activity. Methods UGT-mediated...

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• Modulation of UDP-glucuronidation by acridinone antitumor agents C-1305 and C-1311 in HepG2 and HT29 cell lines, despite slight impact in noncellular systems.

  Publication

  • A. Bejrowska
  • M. Pawłowska
  • A. Mróz
  • Z. Mazerska

  - Pharmacological Reports - Year 2018

  Background Among the studied antitumor acridinone derivatives developed in our laboratory, 5-dimethylaminopropylamino-8-hydroxytriazoloacridinone (C-1305) and 5-diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311) exhibited cytotoxic and antitumor properties against several cancer types and were selected to be evaluated in preclinical and early-phase clinical trials. In the present work, we investigated the impact of C-1305...

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Year 2015

• New generation of analytical tests based on the assessment of enzymatic and nuclear receptor activity changes induced by environmental pollutants

  Publication

  • A. Bejrowska
  • B. Kudłak
  • K. Owczarek
  • N. Jatkowska
  • J. Namieśnik
  • Z. Mazerska

  - TRAC-TRENDS IN ANALYTICAL CHEMISTRY - Year 2015

  Analytical methods show great potential in biological tests. The analysis of biological response that results from environmental pollutant exposure allows: (i) prediction of the risk of toxic effects and (ii) provision of the background for the development of markers of the toxicants presence. Bioanalytical tests based on changes in enzymatic activity and nuclear receptor action provide extremely high specificity and sensitivity....

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Year 2014

• The II phase metabolism of endogenous and exogenous compounds, including antitumor chemotherapeutics

  Publication

  • Z. Mazerska
  • A. Mróz
  • A. Bejrowska
  • B. Borowa-Mazgaj
  • A. Potęga
  • E. Augustin

  - Year 2014

  The II phase metabolism, it is a set of metabolism and excretion pathways of endogenous as well as exogenous compounds including xenobiotics. UDP-glucuronyltransferases (UGTs; EC 2.4.1.17) are the most crucial representatives of II phase enzymes, which are responsible for the transformation of bilirubine and bile acids, steroids and thyroid hormones and lipids. Exogenous compounds, including drugs, carcinogens, environmental pollutants...