Year 2024

• CHEMOTHERAPY-MEDIATED COMPLICATIONS OF WOUND HEALING. AN UNDERSTUDIED SIDE EFFECT

  Publication

  • P. Słonimska
  • P. Sachadyn
  • J. Zieliński
  • M. Skrzypski
  • M. Pikuła

  - Advances in Wound Care - Year 2024

  Significance: Chemotherapy is a primary method to treat cancer, but while cytotoxic drugs are designed to target rapidly dividing cancer cells, they can also affect other cell types, including dermal cells and macrophages involved in wound healing, which often leads to the development of chronic wounds. The situation becomes even more severe when chemotherapy is combined with surgical tumor excision. Recent advances: Despite its...

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Year 2022

• Regenerative Drug Discovery Using Ear Pinna Punch Wound Model in Mice

  Publication

  • P. Sosnowski
  • P. Sass
  • P. Słonimska
  • R. Płatek
  • J. Kamińska
  • J. Baczyński-Keller
  • P. Mucha
  • G. Peszyńska-Sularz
  • A. Czupryn
  • M. Pikuła... and 5 others

  - Pharmaceuticals - Year 2022

  The ear pinna is a complex tissue consisting of the dermis, cartilage, muscles, vessels, and nerves. Ear pinna healing is a model of regeneration in mammals. In some mammals, including rabbits, punch wounds in the ear pinna close spontaneously; in common-use laboratory mice, they remain for life. Agents inducing ear pinna healing are potential regenerative drugs. We tested the effects of selected bioactive agents on 2 mm ear pinna...

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