Year 2012

• Antifungal Activity of Homoaconitate and Homoisocitrate Analogs

  Publication

  • M. J. Milewska
  • M. Prokop
  • I. Gabriel
  • M. Wojciechowski
  • S. Milewski

  - MOLECULES - Year 2012

  Thirteen structural analogs of two initial intermediates of the L-alpha-aminoadipate pathway of L-lysine biosynthesis in fungi have been designed and synthesized, including fluoro- and epoxy-derivatives of homoaconitate and homoisocitrate. Some of the obtainedcompounds exhibited at milimolar range moderate enzyme inhibitory properties against homoaconitase and/or homoisocitrate dehydrogenase of Candida albicans. The structural...

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Year 2010

• Enzymes of the lysine biosynthetic pathway as targets for antifungals ?

  Publication

  • I. Gabriel
  • P. Szweda
  • K. Kur
  • M. Prokop
  • M. J. Milewska
  • S. Milewski

  - FEBS Journal - Year 2010

  Systemic infections caused by human pathogenic fungi in immunocompromized patients continue to be one of the important clinical problems. Limited availability of safe and efficacious antifungal chemotherapeutics and emerging resistance to existing drugs stimulates search for novel molecular targets for antifungals. The α-aminoadipate pathway (AAP) of L-lysine biosynthesis is unique in fungi and thus has been so far considered...

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Year 2009

• An Improved Synthesis of Trisodium (R)-Homocitrate from Citric Acid

  Publication

  • M. Prokop
  • M. J. Milewska

  - POLISH JOURNAL OF CHEMISTRY - Year 2009

  A method of synthesis of trisodium (R)-homocitrate starting from citric acid is reported. The procedure affords the final product of high optical purity with satisfactory yield.

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• N-Alkyl Derivatives of L-Glutamine As Inhibitors of Glutamine - Utilizing Enzymes

  Publication

  • M. Prokop
  • J. Czarnecka
  • M. J. Milewska

  - ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES - Year 2009

  A general facile method to synthesize the N-gamma-alkyl and N-gamma,N-gamma-dialkyl derivatives of L-glutamine (1a-d) from L-glutamic acid as a starting substrate is presented. The obtained compounds are shown to inhibit three diferent glutamine-utilizing enzymes, namely: glutaminase, gamma-glutamyl transpeptidase, and glucosamine-6-phosphate synthase, with inhibitory constants within the milimolar range.