N-Alkyl Derivatives of L-Glutamine As Inhibitors of Glutamine - Utilizing Enzymes

Marta Prokop; Justyna Czarnecka; Maria Jolanta Milewska

N-Alkyl Derivatives of L-Glutamine As Inhibitors of Glutamine - Utilizing Enzymes

Abstract

A general facile method to synthesize the N-gamma-alkyl and N-gamma,N-gamma-dialkyl derivatives of L-glutamine (1a-d) from L-glutamic acid as a starting substrate is presented. The obtained compounds are shown to inhibit three diferent glutamine-utilizing enzymes, namely: glutaminase, gamma-glutamyl transpeptidase, and glucosamine-6-phosphate synthase, with inhibitory constants within the milimolar range.

Authors (3)

Marta Prokop
Justyna Czarnecka
Maria Jolanta Milewska prof. dr hab. inż.

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Category:: Articles
Type:: artykuł w czasopiśmie wyróżnionym w JCR
Published in:: ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES no. 64c, pages 631 - 636,
ISSN: 0939-5075
Language:: English
Publication year:: 2009
Bibliographic description:: Prokop M., Czarnecka J., Milewska M.: N-Alkyl Derivatives of L-Glutamine As Inhibitors of Glutamine - Utilizing Enzymes// ZEITSCHRIFT FUR NATURFORSCHUNG C-A JOURNAL OF BIOSCIENCES. -Vol. 64c, nr. iss. 9/10 (2009), s.631-636
Verified by:: Gdańsk University of Technology