Assessment of the ability of application of folic acid and/or transferrin as a linkers between conjugates of quantum dots with unsymmetrical bisacridines to enhance their selectivity and cytotoxicity against lung and prostate cancer cells.

This project aims to assessment of the ability of folic acid and/or transferrin application as a linkers between conjugates of quantum dots with unsymmetrical bisacridines (UAs) to enhance their selectivity and cytotoxicity against lung and prostate cancer cells. The results of proposed project will extend the basic knowledge about biological activity of UAs conjugated with QD, as well as the effect of using folic acid and transferrin as a targeting linker studied conjugates to cancer cells. Moreover, the planned research will help to design the individual scheme of anticancer therapy using different linker, as drug delivery system to cancer cells with overexpression of different receptors on the membrane surface. The results of these studies may be commercialized in the future.

Details

Financial Program Name:: PRELUDIUM
Organization:: Narodowe Centrum Nauki (NCN) (National Science Centre)
Agreement:: UMO-2020/37/N/NZ7/01979 z dnia 2021-01-14
Realisation period:: 2021-01-14 - 2023-01-13
Project manager:: dr inż. Joanna Pilch
Realised in:: Department of Pharmaceutical Technology and Biochemistry
Project's value:: 139 998.00 PLN
Request type:: National Research Programmes
Domestic:: Domestic project
Verified by:: Gdańsk University of Technology

Papers associated with that project

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total: 4

Year 2024

In vitro biological evaluation of a novel folic acid-targeted receptor quantum dot−β−cyclodextrin carrier for C-2028 unsymmetrical bisacridine in the treatment of human lung and prostate cancers
Publication
- J. Pilch
- A. Potęga
- P. Kowalik
- A. Kowalczyk
- P. Bujak
- A. Kasprzak
- E. Paluszkiewicz
- A. M. Nowicka
- Pharmacological Reports - Year 2024
Traditional small-molecule chemotherapeutics usually do not distinguish tumors from healthy tissues. However, nanotechnology creates nanocarriers that selectively deliver drugs to their site of action. This work is the next step in the development of the quantum dot−β−cyclodextrin−folic acid (QD−β−CD−FA) platform for targeted and selected delivery of C−2028 unsymmetrical bisacridine in cancer therapy.Herein, we report an initial...

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Year 2023

pH-Responsive Drug Delivery Nanoplatforms as Smart Carriers of Unsymmetrical Bisacridines for Targeted Cancer Therapy
Publication
- J. Pilch
- A. Potęga
- A. Kowalczyk
- A. Kasprzak
- P. Kowalik
- P. Bujak
- E. Paluszkiewicz
- E. Augustin
- A. M. Nowicka
- Pharmaceutics - Year 2023
Selective therapy and controlled drug release at an intracellular level remain key challenges for effective cancer treatment. Here, we employed folic acid (FA) as a self-navigating molecule in nanoconjugates containing quantum dots (QDs) and β-cyclodextrin (β-CD) for the delivery of antitumor unsymmetrical bisacridine compound (C-2028) to lung and prostate cancers as well as normal cells. The bisacridine derivative can form the...

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Year 2022

Foliate-Targeting Quantum Dots-β-Cyclodextrin Nanocarrier for Efficient Delivery of Unsymmetrical Bisacridines to Lung and Prostate Cancer Cells
Publication
- J. Pilch
- P. Kowalik
- A. Kowalczyk
- P. Bujak
- A. Kasprzak
- E. Paluszkiewicz
- E. Augustin
- A. M. Nowicka
- INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - Year 2022
Targeted drug delivery by nanocarriers molecules can increase the efficiency of cancer treatment. One of the targeting ligands is folic acid (FA), which has a high affinity for the folic acid receptors, which are overexpressed in many cancers. Herein, we describe the preparation of the nanoconjugates containing quantum dots (QDs) and β-cyclodextrin (β-CD) with foliate-targeting properties for the delivery of anticancer compound...

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Nanocząstki w chemioterapii: charakterystyka, strategie projektowania, mechanizm wnikania oraz degradacja wewnątrzkomórkowa
Publication
- J. Pilch
- Postępy Biochemii - Year 2022
Pomimo znaczącego postępu w leczeniu nowotworów skuteczne metody ich leczenia po-zostają ograniczone. Wciąż jedną z głównych metod terapii pozostaje chemioterapia, jednakże często wywołuje ona wiele efektów ubocznych. Związane jest to m. in. z brakiem istotnych różnic pomiędzy komórkami nowotworowymi a prawidłowymi, właściwościami fizykochemicznymi samych chemioterapeutyków, a także zjawiskiem lekooporności. W celu obniżenia...

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