Assessment of the ability of application of folic acid and/or transferrin as a linkers between conjugates of quantum dots with unsymmetrical bisacridines to enhance their selectivity and cytotoxicity against lung and prostate cancer cells. - Project - MOST Wiedzy

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Assessment of the ability of application of folic acid and/or transferrin as a linkers between conjugates of quantum dots with unsymmetrical bisacridines to enhance their selectivity and cytotoxicity against lung and prostate cancer cells.

This project aims to assessment of the ability of folic acid and/or transferrin application as a linkers between conjugates of quantum dots with unsymmetrical bisacridines (UAs) to enhance their selectivity and cytotoxicity against lung and prostate cancer cells. The results of proposed project will extend the basic knowledge about biological activity of UAs conjugated with QD, as well as the effect of using folic acid and transferrin as a targeting linker studied conjugates to cancer cells. Moreover, the planned research will help to design the individual scheme of anticancer therapy using different linker, as drug delivery system to cancer cells with overexpression of different receptors on the membrane surface. The results of these studies may be commercialized in the future.

Details

Project's funding:
PRELUDIUM
Agreement:
UMO-2020/37/N/NZ7/01979 z dnia 2021-01-14
Realisation period:
2021-01-14 - 2023-01-13
Project manager:
mgr inż. Joanna Pilch
Realised in:
Department of Pharmaceutical Technology and Biochemistry
Project's value:
139 998.00 PLN
Request type:
National Research Programmes
Domestic:
Domestic project
Verified by:
Gdańsk University of Technology

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