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- Project's acronym:
- BIONANOVA
- Financial Program Name:
- TECHMATSTRATEG
- Organization:
- Narodowe Centrum Badań i Rozwoju (NCBR) (The National Centre for Research and Development)
- Agreement:
- TECHMATSTRATEG2/410747/11/NCBR/2019 z dnia 2019-09-09
- Realisation period:
- 2019-09-01 - 2023-02-28
- Research team leader:
- prof. dr hab. inż. Paweł Sachadyn
- Realised in:
- Department of Microbiology
- External institutions
participating in project: -
- Innovabion sp. z o.o. (Poland)
- Uniwersytet Gdański (Poland)
- Gdański Uniwersytet Medyczny (Poland)
- Project's value:
- 25 133 525.55 PLN
- Request type:
- National Research Programmes
- Domestic:
- Domestic project
- Verified by:
- Gdańsk University of Technology
Papers associated with that project
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total: 3
Catalog Projects
Year 2023
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Between therapy effect and false-positive result in animal experimentation
PublicationDespite the animal models’ complexity, researchers tend to reduce the number of animals in experiments for expenses and ethical concerns. This tendency makes the risk of false-positive results, as statistical significance, the primary criterion to validate findings, often fails if testing small samples. This study aims to highlight such risks using an example from experimental regenerative therapy and propose a machine-learning...
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Release systems based on self-assembling RADA16-I hydrogels with a signal sequence which improves wound healing processes
PublicationSelf-assembling peptides can be used for the regeneration of severely damaged skin. They can act as scaffolds for skin cells and as a reservoir of active compounds, to accelerate scarless wound healing. To overcome repeated administration of peptides which accelerate healing, we report development of three new peptide biomaterials based on the RADA16-I hydrogel functionalized with a sequence (AAPV) cleaved by human neutrophil elastase...
Year 2022
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Examination of epigenetic inhibitor zebularine in treatment of skin wounds in healthy and diabetic mice
PublicationDNA methyltransferase inhibitor zebularine was proven to induce regeneration in the ear pinna in mice. We utilized a dorsal skin wound model to further evaluate this epigenetic inhibitor in wound healing. Full-thickness excisional wounds were made on the dorsum of 2 and 10-month-old healthy BALB/c and 3 and 8-month-old diabetic (db/db) mice, followed by topical or intraperitoneal zebularine delivery. Depending on the strain, age,...
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