Chitosan-Based Material and a Copine-7 Peptide Derivative as a Chondrogenesis Stimulator in Adipose-Derived Stromal Cells - Publication - Bridge of Knowledge

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Chitosan-Based Material and a Copine-7 Peptide Derivative as a Chondrogenesis Stimulator in Adipose-Derived Stromal Cells

Abstract

The natural healing process of cartilage injuries often fails to fully restore the tissue’s biological and mechanical functions. Cartilage grafts are costly and require surgical intervention, often associated with complications such as intraoperative infection and rejection by the recipient due to ischemia. Novel tissue engineering technologies aim to ideally fill the cartilage defect to prevent disease progression or regenerate damaged tissue. Despite many studies on designing biocompatible composites to stimulate chondrogenesis, only few focus on peptides and carriers that promote stem cell proliferation or differentiation to promote healing. Our research aimed to design a carbohydrate chitosan-based biomaterial to stimulate stem cells into the chondrogenesis pathway. Our strategy was to combine chitosan with a novel peptide (UG28) that sequence was based on the copin protein. The construct stimulated human adipose-derived stem cells (AD-SCs) cells to undergo chondrogenic differentiation. Chitosan 75/500 allows AD-SCs to grow and has no harmful effects on the cells. The combination of UG28 peptide with the chitosan composite offers promising properties for cell differentiation, indicating its potential for clinical applications in cartilage regeneration.

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DOI:
Digital Object Identifier (open in new tab) 10.1016/j.biopha.2024.117683
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Category:
Articles
Type:
artykuły w czasopismach dostępnych w wersji elektronicznej [także online]
Published in:
BIOMEDICINE & PHARMACOTHERAPY
ISSN: 0753-3322
Language:
English
Publication year:
2024
Bibliographic description:
Tymińska A., Karska N., Skoniecka A., Zawrzykraj M., Banach-Kopeć A., Mania S., Tylingo R., Jacek Z., Kondej K., Gurzawska-Comis K., Skowron P., Chitosan-Based Material and a Copine-7 Peptide Derivative as a Chondrogenesis Stimulator in Adipose-Derived Stromal Cells, BIOMEDICINE & PHARMACOTHERAPY, 2024,10.1016/j.biopha.2024.117683
DOI:
Digital Object Identifier (open in new tab) 10.1016/j.biopha.2024.117683
Sources of funding:
Verified by:
Gdańsk University of Technology

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