A study on the protection of methionine and the reduction of methionine sulfoxide in methionine-containing analogues of the growth-modeling factor Gly-His-Lys

Monika Kukowska; Magdalena Kukowska-Kaszuba; Krystyna Dzierzbicka

doi:10.1016/j.tetlet.2014.12.009

A study on the protection of methionine and the reduction of methionine sulfoxide in methionine-containing analogues of the growth-modeling factor Gly-His-Lys

Abstract

The protection of methionine and the reduction of methionine sulfoxide in methionine-containing analogues of Gly-His-Lys are described. The peptides were synthesized by a solid-phase method using the standard Fmoc procedure. Simultaneous deprotection of the peptide side chain and liberation from the resin were achieved using an appropriate TFA cocktail. The TFA cocktail was selected to minimize oxidation of the methionine residue. The reversible method of methionine oxidation was also studied. Selective identification and quantitative analysis of the methionine-containing peptides are based on an LC–MS study.

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Category:: Articles
Type:: artykuł w czasopiśmie wyróżnionym w JCR
Published in:: TETRAHEDRON LETTERS no. 56, edition 3, pages 525 - 528,
ISSN: 0040-4039
Language:: English
Publication year:: 2015
Bibliographic description:: Kukowska M., Kukowska-Kaszuba M., Dzierzbicka K.: A study on the protection of methionine and the reduction of methionine sulfoxide in methionine-containing analogues of the growth-modeling factor Gly-His-Lys// TETRAHEDRON LETTERS. -Vol. 56, iss. 3 (2015), s.525-528
DOI:: Digital Object Identifier (open in new tab) 10.1016/j.tetlet.2014.12.009
Verified by:: Gdańsk University of Technology