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Abstract
Chronic rhinosinusitis (CRS) is a significant public health problem. Bacterial colonization and impaired mucociliary clearance play a significant role in the inflammatory process. Several inflammatory pathways and host defense elements are altered in CRS, which may contribute to observed differences in the microbiome. To date, researching CRS has been difficult due to limited access to the studied tissue and a lack of available biomarkers. Ongoing scientific research is increasingly based on simple and objective analytical methods, including sensors, detection with PCR, and sequencing. Future research on microbiota and human factors should also include genomics, transcriptomics, and metabolomics approaches. This report analyzes the changes that occur in the paranasal sinuses of people with acute and chronic rhinosinusitis, the composition of the microbiota, the human genetic markers that may shed light on the predisposition to CRS, and the advantages and disadvantages of classical and molecular diagnostic methods, as well as addressing the difficulties of sinusitis treatment.
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Authors (2)
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Michał Michalik
- Medical Center MML
Cite as
Full text
- Publication version
- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.3390/ijms25063201
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Details
- Category:
- Articles
- Type:
- artykuły w czasopismach dostępnych w wersji elektronicznej [także online]
- Published in:
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
ISSN: 1661-6596 - Language:
- English
- Publication year:
- 2024
- Bibliographic description:
- Michalik M., Krawczyk B., Chronic Rhinosinusitis—Microbiological Etiology, Potential Genetic Markers, and Diagnosis, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024,10.3390/ijms25063201
- DOI:
- Digital Object Identifier (open in new tab) 10.3390/ijms25063201
- Sources of funding:
-
- COST_FREE
- Verified by:
- Gdańsk University of Technology
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