Search
Abstract
Meat consumption represents a dietary risk factor increasing the incidence of common cancers, probably due to carcinogenic amines (HAAs) formed upon meat heating. Interestingly, cancers whose incidence is increased by meat consumption, are decreased in populations consuming brassica vegetables regularly. This inverse correlation is attributed to brassica anticarcinogenic components, especially isothiocyanates (ITCs) that stimulate detoxification of food carcinogens. However, ITC reactivity towards amines generating stable thioureas, may also decrease mutagenicity of processed meat. We confirmed here that combining meat with cabbage (fresh or lyophilized), in proportions found in culinary recipes, limited by 17–20% formation of HAAs and significantly lowered mutagenic activity of fried burgers. Moreover, MeIQx mutagenicity was lowered in the presence of ITCs, as well as for synthetic ITC-MeIQx conjugates. This suggests that formation of thioureas could lead to chemical detoxification of food carcinogens, reducing the cancer risk associated with meat consumption.
Citations
-
1 1
CrossRef
-
0
Web of Science
-
1 1
Scopus
Authors (6)
Cite as
Full text
- Publication version
- Accepted or Published Version
- License
-
open in new tab
Keywords
Details
- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
-
FOOD CHEMISTRY
no. 157,
pages 105 - 110,
ISSN: 0308-8146 - Language:
- English
- Publication year:
- 2014
- Bibliographic description:
- Lewandowska A., Przychodzeń W., Kusznierewicz B., Kołodziejski D., Namieśnik J., Bartoszek-Pączkowska A.: Isothiocyanates may chemically detoxify mutagenic amines formed in heat processed meat// FOOD CHEMISTRY. -Vol. 157, (2014), s.105-110
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.foodchem.2014.01.082
- Verified by:
- Gdańsk University of Technology
seen 157 times
Recommended for you
Genotoxic properties of glucosinolates and isothiocyanates present in Brassica vegetables
- D. Kołodziejski,
- A. Śmiechowska,
- M. Główczyńska
- + 1 authors
Naphthyl-vs. anthrylpyridine-2,6-dicarboxamides in cation binding studies. Synthesis and spectroscopic properties
- N. Łukasik,
- E. Wagner-Wysiecka,
- V. Hubscher-Bruder
- + 3 authors