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Mitochondrial DNA copy number and trimethylamine levels in the blood: New insights on cardiovascular disease biomarkers
Abstract
Among cardiovascular disease (CVD) biomarkers, the mitochondrial DNA copy number (mtDNAcn) is a promising candidate. A growing attention has been also dedicated to trimethylamine-N-oxide (TMAO), an oxidative derivative of the gut metabolite trimethylamine (TMA). With the aim to identify biomarkers predictive of CVD, we investigated TMA, TMAO, and mtDNAcn in a population of 389 coronary artery disease (CAD) patients and 151 healthy controls, in association with estab-lished risk factors for CVD (sex, age, hypertension, smoking, diabetes, glomerular filtration rate [GFR]) and troponin, an established marker of CAD. MtDNAcn was significantly lower in CAD patients; it correlates with GFR and TMA, but not with TMAO. A biomarker including mtDNAcn, sex, and hypertension (but neither TMA nor TMAO) emerged as a good predictor of CAD. Our findings support the mtD-NAcn as a promising plastic biomarker, useful to monitor the exposure to risk factors and the efficacy of preventive interventions for a personalized CAD risk reduction.
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Authors (10)
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Laura Bordoni
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Irene Petracci
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Iwona Pelikant-Malecka
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Adrianna Radulska
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Marco Piangerelli
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Joanna J. Samulak
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Lukasz Lewicki
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Rosita Gabbianelli
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Robert A. Olek
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Full text
- Publication version
- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.1096/fj.202100056R
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- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
-
FASEB JOURNAL
no. 35,
ISSN: 0892-6638 - Language:
- English
- Publication year:
- 2021
- Bibliographic description:
- Bordoni L., Petracci I., Pelikant-Malecka I., Radulska A., Piangerelli M., Samulak J. J., Lewicki L., Kalinowski L., Gabbianelli R., Olek R. A.: Mitochondrial DNA copy number and trimethylamine levels in the blood: New insights on cardiovascular disease biomarkers// FASEB JOURNAL -, (2021),
- DOI:
- Digital Object Identifier (open in new tab) 10.1096/fj.202100056r
- Verified by:
- Gdańsk University of Technology
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