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Search results for: BIOMARKERS, CARDIOVASCULAR DISEASE, HYPERTENSION, MITOCHONDRIAL DNA, SEX, TMAO
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Mitochondrial DNA copy number and trimethylamine levels in the blood: New insights on cardiovascular disease biomarkers
PublicationAmong cardiovascular disease (CVD) biomarkers, the mitochondrial DNA copy number (mtDNAcn) is a promising candidate. A growing attention has been also dedicated to trimethylamine-N-oxide (TMAO), an oxidative derivative of the gut metabolite trimethylamine (TMA). With the aim to identify biomarkers predictive of CVD, we investigated TMA, TMAO, and mtDNAcn in a population of 389 coronary artery disease...
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Gender-Related Differences in Trimethylamine and Oxidative Blood Biomarkers in Cardiovascular Disease Patients
PublicationGender differences in the burden of cardiovascular disease (CVD) have been observed worldwide. In this study, plasmatic levels of trimethylamine (TMA) and blood oxidative biomarkers have been evaluated in 358 men (89 controls and 269 CVD patients) and 189 women (64 control and 125 CVD patients). The fluorescence technique was applied to determine erythrocyte membrane fluidity using 1,6-diphenyl-1,3,5-hexatriene (DPH) and Laurdan,...
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Trimethylamine N-oxide and the reverse cholesterol transport in cardiovascular disease: a cross-sectional study
PublicationThe early atherosclerotic lesions develop by the accumulation of arterial foam cells derived mainly from cholesterol-loaded macrophages. Therefore, cholesterol and cholesteryl ester transfer protein (CETP) have been considered as causative in atherosclerosis. Moreover, recent studies indicate the role of trimethylamine N-oxide (TMAO) in development of cardiovascular disease (CVD). The current study aimed to investigate the association...
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Mitochondrial DNA
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Pet Ownership and the Risk of Arterial Hypertension and Cardiovascular Disease
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Mitochondrial DNA levels in Huntington disease leukocytes and dermal fibroblasts
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Mitochondrial DNA Part A
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Naturally occurring mitochondrial DNA heteroplasmy in the MRL mouse
PublicationThe MRL/MpJ mouse is an inbred laboratory strain of Mus musculus, known to exhibit enhanced autoimmunity, increased wound healing, and increased regeneration properties. We report the full-length mitochondrial DNA (mtDNA) sequence of the MRL mouse (Accession # EU450583), and characterize the discovery of two naturally occurring heteroplasmic sites. The first is a T3900C substitution in the TpsiCloop of the tRNA methionine gene...
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2-Methoxyestradiol and Hydrogen Peroxide as Promising Biomarkers in Parkinson’s Disease
PublicationEstrogens function in numerous physiological processes including controlling brain cell growth and differentiation. 2-Meth- oxestradiol (2-ME2), a 17β-estradiol (E2) metabolite, is known for its anticancer effects as observed both in vivo and in vitro. 2-ME2 affects all actively dividing cells, including neurons. The study aimed to determine whether 2-ME2 is a potentially cancer-protective or rather neurodegenerative agent in a...
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Hypertension and cardiovascular disease in women: Progress towards better understanding of gender‐specific differences?
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Depression and anxiety in cardiovascular disease
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Molecular differences in mitochondrial DNA (mtDNA) genomes of dogs with malignant mammary tumours
Open Research DataThe aim of this study was to determine molecular defects in mitochondrial DNA with the use of large-scale genome analysis in malignant canine mammary gland tumours and indicate whether these changes were linked with the carcinogenesis process. With the use of the NGS technology, we sequenced 27 samples of mtDNA isolated from blood and tumours obtained...
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An appropriate SCORE to assess cardiovascular risk in hypertension?
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Mitochondrial DNA Part B-Resources
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Arterial stiffness, central hemodynamics, and cardiovascular risk in hypertension
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Impact of abdominal obesity on the frequency of hypertension and cardiovascular disease in Poland – Results from the IDEA study (International Day for the Evaluation of Abdominal Obesity)
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Are advanced glycation end-products specific biomarkers for Alzheimer's disease?
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Managing comorbid cardiovascular disease and sleep apnea with pharmacotherapy
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EDITORIALHypertension and cardiovascular disease: Is arterial stiffness the heart of the matter?
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Plasma Lipid Composition and Risk of Developing Cardiovascular Disease
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Identification of Mitochondrial DNA (NUMTs) in the Nuclear Genome of Daphnia magna
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cGMP level in idiopathic Parkinson’s disease patients with and without cardiovascular disease – A pilot study
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Oxidative stress in humans: validation of biomarkers of DNA damage
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Impaired baroreflex sensitivity as a potential marker of cardiovascular risk in hypertension
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Cardiovascular Function in Obstructive Sleep Apnea Patients with Controlled Hypertension
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Proteomic and lipidomic biomarkers in the diagnosis and progression of inflammatory bowel disease – a review
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Mitochondrial DNA of Anisakis simplex S.S. as a Potential Tool for Differentiating Populations
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Molecular differences in mitochondrial DNA genomes of dogs with malignant mammary tumours
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Analysis of differences in the stability of proteins encoded in mitochondrial DNA of model organisms
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The polypill: an emerging treatment alternative for secondary prevention of cardiovascular disease
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Association of Oral Status and Early Primary Hypertension Biomarkers among Children and Adolescents
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Women’s health, cardiovascular risk and hypertension: the perspective still needs to improve
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Altered levels of circulating nuclear and mitochondrial DNA in patients with Papillary Thyroid Cancer
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Comparative Analysis of CpG Sites and Islands Distributed in Mitochondrial DNA of Model Organisms
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Hypertension and coronary artery disease: Mechanistic insights and therapeutic challenges
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JRSM Cardiovascular Disease
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European Society of Hypertension Working Group on Obesity: obesity drugs and cardiovascular outcomes
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SCORE model underestimates cardiovascular risk in hypertensive patients: Results of the Polish Hypertension Registry
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A response to “Cardiovascular disease and obstructive sleep apnea: an underappreciated role for increased platelet activity?”
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Oxidatively Damaged DNA/Oxidative Stress in Children with Celiac Disease
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Oxidative DNA damage in cancer patients: a cause or a consequence of the disease development?
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Relationship between selected DNA polymorphisms and coronary artery disease complications
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American Journal of Cardiovascular Disease
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Journal of Cardiovascular Development and Disease
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Journal of Cardiovascular Disease Research
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Therapeutic Advances in Cardiovascular Disease
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Add-On Therapy with a Nighttime Dose of Doxazosin in Patients with Uncontrolled Hypertension: Effects on Autonomic Modulation of the Cardiovascular System
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Combination therapy in the management of hypertension — current problem in Poland. Expert consensus statement of the Polish Society of Hypertension and Polish Cardiac Society Working Group on Cardiovascular Pharmacotherapy
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Single-pill combinations (SPCs) and treatment of arterial hypertension in Poland. Expert consensus statement of the Polish Society of Hypertension and Polish Cardiac Society Working Group on Cardiovascular Pharmacotherapy
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Increased time varying heart rate and cardiovascular risk in hypertension – Benefit of selective I(f)channel inhibitor?
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