More Than just Antioxidants: Redox-Active Components and Mechanisms Shaping Redox Signalling Network

Monika Baranowska; Patrycja Jakubek; Agnieszka Bartoszek-Pączkowska

doi:10.3390/antiox11122403

More Than just Antioxidants: Redox-Active Components and Mechanisms Shaping Redox Signalling Network

Abstract

settingsOrder Article Reprints This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessReview More Than just Antioxidants: Redox-Active Components and Mechanisms Shaping Redox Signalling Network by Monika Kuczyńska,Patrycja Jakubek andAgnieszka Bartoszek *ORCID Faculty of Chemistry, Gdańsk University of Technology, 80-233 Gdańsk, Poland * Author to whom correspondence should be addressed. Antioxidants 2022, 11(12), 2403; https://doi.org/10.3390/antiox11122403 (registering DOI) Received: 26 September 2022 / Revised: 28 November 2022 / Accepted: 30 November 2022 / Published: 4 December 2022 (This article belongs to the Special Issue 10th Anniversary of Antioxidants—Review Collection) Download Versions Notes Abstract The concept of oxidative stress as a condition underlying a multitude of human diseases has led to immense interest in the search for antioxidant-based remedies. The simple and intuitive story of “the bad” reactive oxygen species (ROS) and “the good” antioxidants quickly (and unsurprisingly) lead to the commercial success of products tagged “beneficial to health” based solely on the presence of antioxidants. The commercial success of antioxidants by far preceded the research aimed at understanding the exact redox-related mechanisms that are in control of shaping the states of health and disease. This review describes the redox network formed by the interplay of ROS with cellular molecules and the resulting regulation of processes at the genomic and proteomic levels. Key players of this network are presented, both involved in redox signalling and control of cellular metabolism linked to most, if not all, physiological processes. In particular, this review focuses on the concept of reductive stress, which still remains less well-established compared to oxidative stress.

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Articles

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artykuły w czasopismach

Published in:

Antioxidants no. 11,
ISSN: 2076-3921

Language:

English

Publication year:

2022

Bibliographic description:

Baranowska M., Jakubek P., Bartoszek-Pączkowska A.: More Than just Antioxidants: Redox-Active Components and Mechanisms Shaping Redox Signalling Network// Antioxidants -Vol. 11,iss. 12 (2022), s.2403-

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