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Natural Products Counteracting Cardiotoxicity during Cancer Chemotherapy: The Special Case of Doxorubicin, a Comprehensive Review
Abstract
Cardiotoxicity is a frequent undesirable phenomenon observed during oncological treatment that limits the therapeutic dose of antitumor drugs and thus may decrease the effec-‐‑ tiveness of cancer eradication. Almost all antitumor drugs exhibit toxic properties towards cardiac muscle. One of the underlying causes of cardiotoxicity is stimulation of oxidative stress by chem-‐‑ otherapy. This suggests that an appropriately designed diet or dietary supplements based on edi-‐‑ ble plants rich in antioxidants could decrease the toxicity of antitumor drugs and diminish the risk of cardiac failure. This comprehensive review compares the cardioprotective efficacy of edible plant extracts and foodborne phytochemicals whose beneficial activity was demonstrated in vari-‐‑ ous models in vivo and in vitro. The studies selected for this review concentrated on a frequently applied in cancer therapy anthracycline antibiotic – doxorubicin -‐‑ as the oxidative stress and car-‐‑ diotoxicity inducing agent.
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Authors (7)
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Vanja Todorovic
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Sladjana Sobajic
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Jamal Mahajna
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Marko Gerić
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Josep Tur prof.
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- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.3390/ijms221810037
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- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
no. 22,
ISSN: 1661-6596 - Language:
- English
- Publication year:
- 2021
- Bibliographic description:
- Koss-Mikołajczyk I., Todorovic V., Sobajic S., Mahajna J., Gerić M., Tur J., Bartoszek-Pączkowska A.: Natural Products Counteracting Cardiotoxicity during Cancer Chemotherapy: The Special Case of Doxorubicin, a Comprehensive Review// INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES -Vol. 22,iss. 18 (2021), s.10037-
- DOI:
- Digital Object Identifier (open in new tab) 10.3390/ijms221810037
- Verified by:
- Gdańsk University of Technology
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