Search
Natural Products Counteracting Cardiotoxicity during Cancer Chemotherapy: The Special Case of Doxorubicin, a Comprehensive Review
Abstract
Cardiotoxicity is a frequent undesirable phenomenon observed during oncological treatment that limits the therapeutic dose of antitumor drugs and thus may decrease the effec-‐‑ tiveness of cancer eradication. Almost all antitumor drugs exhibit toxic properties towards cardiac muscle. One of the underlying causes of cardiotoxicity is stimulation of oxidative stress by chem-‐‑ otherapy. This suggests that an appropriately designed diet or dietary supplements based on edi-‐‑ ble plants rich in antioxidants could decrease the toxicity of antitumor drugs and diminish the risk of cardiac failure. This comprehensive review compares the cardioprotective efficacy of edible plant extracts and foodborne phytochemicals whose beneficial activity was demonstrated in vari-‐‑ ous models in vivo and in vitro. The studies selected for this review concentrated on a frequently applied in cancer therapy anthracycline antibiotic – doxorubicin -‐‑ as the oxidative stress and car-‐‑ diotoxicity inducing agent.
Citations
-
1 2
CrossRef
-
0
Web of Science
-
1 4
Scopus
Authors (7)
-
Vanja Todorovic
-
Sladjana Sobajic
-
Jamal Mahajna
-
Marko Gerić
-
Josep Tur prof.
Cite as
Full text
- Publication version
- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.3390/ijms221810037
- License
-
open in new tab
Keywords
Details
- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
-
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
no. 22,
ISSN: 1661-6596 - Language:
- English
- Publication year:
- 2021
- Bibliographic description:
- Koss-Mikołajczyk I., Todorovic V., Sobajic S., Mahajna J., Gerić M., Tur J., Bartoszek-Pączkowska A.: Natural Products Counteracting Cardiotoxicity during Cancer Chemotherapy: The Special Case of Doxorubicin, a Comprehensive Review// INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES -Vol. 22,iss. 18 (2021), s.10037-
- DOI:
- Digital Object Identifier (open in new tab) 10.3390/ijms221810037
- Verified by:
- Gdańsk University of Technology
seen 73 times
Recommended for you
Dietary intervention with beetroot juice during doxorubicin cancer chemotherapy in vivo reduces markers of oxidative stress
- J. Łukowicz,
- G. Peszyńska-Sularz,
- A. Cieślak
- + 6 authors
Pharmacomicrobiomics of cell-cycle specific anti-cancer drugs – is it a new perspective for personalized treatment of cancer patients?
- K. Kaźmierczak-Siedlecka,
- N. Bulman,
- P. Ulasiński
- + 5 authors
Influence of Diosmin Treatment on the Level of Oxidative Stress Markers in Patients with Chronic Venous Insufficiency
- M. Feldo,
- M. Woźniak,
- M. Wójciak-Kosior
- + 6 authors
Electrically Conductive Carbon‐based (Bio)‐nanomaterials for Cardiac Tissue Engineering
- N. Jalilinejad,
- M. Rabiee,
- N. Baheiraei
- + 11 authors