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Nitric Oxide-Dependent Pathways as Critical Factors in the Consequences and Recovery after Brain Ischemic Hypoxia
Abstract
Brain ischemia is one of the leading causes of disability and mortality worldwide. Nitric oxide (NO), a molecule that is involved in the regulation of proper blood flow, vasodilation, neuronal and glial activity constitutes the crucial factor that contributes to the development of pathological changes after stroke. One of the early consequences of a sudden interruption in the cerebral blood flow is the massive production of reactive oxygen and nitrogen species (ROS/RNS) in neurons due to NO synthase uncoupling, which leads to neurotoxicity. Progression of apoptotic or necrotic neuronal damage activates reactive astrocytes and attracts microglia or lymphocytes to migrate to place of inflammation. Those inflammatory cells start to produce large amounts of inflammatory proteins, including pathological, inducible form of NOS (iNOS), which generates nitrosative stress that further contributes to brain tissue damage, forming vicious circle of detrimental processes in the late stage of ischemia. S-nitrosylation, hypoxia-inducible factor 1 (HIF-1) and HIF-1-dependent genes activated in reactive astrocytes play essential roles in this process. The review summarizes the roles of NO-dependent pathways in the early and late aftermath of stroke and treatments based on the stimulation or inhibition of particular NO synthases and the stabilization of HIF-1 activity
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Authors (3)
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Joanna M. Wierońska
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Paulina Cieślik
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Full text
- Publication version
- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.3390/biom11081097
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Details
- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
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Biomolecules
no. 11,
ISSN: 2218-273X - Language:
- English
- Publication year:
- 2021
- Bibliographic description:
- Wierońska J. M., Cieślik P., Kalinowski L.: Nitric Oxide-Dependent Pathways as Critical Factors in the Consequences and Recovery after Brain Ischemic Hypoxia// Biomolecules -Vol. 11,iss. 8 (2021), s.1097-
- DOI:
- Digital Object Identifier (open in new tab) 10.3390/biom11081097
- Verified by:
- Gdańsk University of Technology
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