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Abstract
Metabolomics offers a unique approach to study biological systems. Liquid chromatography coupled to mass spectrometry serves as a powerful analytical tool to analyze complex mixtures of metabolites. However, successful metabolomic analysis relies on sample preparation. While untargeted analysis traditionally favors nonselective procedures like liquid-liquid extraction (LLE), these methods can compromise analytical performance due to limited analyte enrichment and potential matrix interferences. Solid-phase extraction (SPE) has emerged as a well-established and versatile technique for this purpose, offering advantages over other traditional methods like LLE. This review explores the applications of SPE and solid-phase microextraction (SPME) in LC-MS-based metabolomics. We discuss various modes of SPE, ranging from conventional flow-through cartridges and plates to approaches involving the dispersion of sorbent in a sample, as well as sorbents, their properties, and the diverse geometries of support materials employed in SPME. This review underscores the potential of emerging extraction protocols to further accelerate metabolomics research.
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- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
-
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
no. 180,
ISSN: 0165-9936 - Language:
- English
- Publication year:
- 2024
- Bibliographic description:
- Młynarczyk M., Belka M., Hewelt-Belka W.: Novel materials and approaches for solid-phase (micro) extraction in LC-MS-based metabolomics// TRAC-TRENDS IN ANALYTICAL CHEMISTRY -, (2024),
- Sources of funding:
-
- IDUB
- Free publication
- Verified by:
- Gdańsk University of Technology
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