Optimizing Ni–Cr patterned boron-doped diamond band electrodes: Doping effects on electrochemical efficiency and posaconazole sensing performance

Anna Danuta Dettlaff; Michał Rycewicz; Łukasz Macewicz; Paweł Rutecki; Mirosław Sawczak; Paul Wittendorp; Shruti Jain; Elizaveta Vereshchagina; Robert Bogdanowicz

doi:10.1016/j.talanta.2024.126519

Optimizing Ni–Cr patterned boron-doped diamond band electrodes: Doping effects on electrochemical efficiency and posaconazole sensing performance

Abstract

There is growing interest in developing diamond electrodes with defined geometries such as, for example, micrometer-sized electrode arrays to acquire signals for electroanalysis. For electroanalytical sensing applications, it is essential to achieve precise conductive patterns on the insulating surface. This work provides a novel approach to boron-doped diamond patterning using nichrome masking for selective seeding on an oxidized silicon substrate. The optimized process involves nichrome deposition, sonication, chemical etching, seeding, and tailored chemical vapor deposition of boron-doped diamond with an intrinsic layer to suppress boron diffusion. Through a systematic investigation, it was determined that isolated boron-doped diamond band electrodes can be efficiently produced on non-conductive silica. Additionally, the influence of boron doping on electrochemical performance was studied, with higher doping enhancing the electrochemical response of band electrodes. To demonstrate sensing capabilities, boron-doped diamond bands were used to detect posaconazole, an antifungal drug, exploiting its electroactive behaviour. A linear correlation between posaconazole concentration and oxidation peak current was observed over 1.43 × 10−8 – 5.71 × 10−6 M with a 1.4 × 10−8 M detection limit. The developed boron-doped diamond microbands could significantly impact the field of electroanalysis, facilitating detection of diverse biologically relevant molecules. Overall, this diamond patterning approach overcomes major challenges towards all-diamond electrochemical sensor chips.

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Authors (9)

Anna Danuta Dettlaff (formerly: Anna Dettlaff) dr inż.
Michał Rycewicz dr inż.
Łukasz Macewicz
Paweł Rutecki
Mirosław Sawczak dr hab. inż.
Paul Wittendorp
Shruti Jain
Elizaveta Vereshchagina
Robert Bogdanowicz dr hab. inż.

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Keywords

BORON-DOPED DIAMOND

Details

Category:

Articles

Type:

artykuły w czasopismach

Published in:

TALANTA.The International Journal of Pure and Applied Analytical Chemistry no. 278,
ISSN: 0039-9140

Language:

English

Publication year:

2024

Bibliographic description:

Dettlaff A., Rycewicz M., Macewicz Ł., Rutecki P., Sawczak M., Wittendorp P., Jain S., Vereshchagina E., Bogdanowicz R.: Optimizing Ni–Cr patterned boron-doped diamond band electrodes: Doping effects on electrochemical efficiency and posaconazole sensing performance// TALANTA.The International Journal of Pure and Applied Analytical Chemistry -Vol. 278, (2024), s.126519-

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