Preparation, characterization and anti-colitis activity of curcumin-asafoetida complex encapsulated in turmeric nanofiber

Sreeraj Gopi; Augustine Amalraj; Shintu Jude; Karthik Varma; T.r. Sreeraj; Józef Haponiuk; Sabu Thomas

doi:10.1016/j.msec.2017.07.037

Preparation, characterization and anti-colitis activity of curcumin-asafoetida complex encapsulated in turmeric nanofiber

Abstract

Ulcerative colitis (UC) is a main form of inflammatory bowel disease (IBD). Asafoetida (ASF) and turmeric have traditionally been used for the treatment of various inflammatory diseases, including UC, because ASF is rich in sulfur compounds and turmeric contains curcumin (CUR). Turmeric nanofiber (TNF), the modified cell wall component of turmeric is considered to play important role in the human diet, health and can be used as a carrier agent to encapsulate bioactive components. A novel gut health product (GHP) was formulated by encapsulation of ASF and CUR complex onto TNF. The GHP was characterized by UPLC, GC-MS, FTIR, XRD, SEM with EDS and DSC studies. GHP was evaluated for anti-colitis activity in a rat model of 5% dextran sulfate sodium (DSS) induced UC. Treatment with GHP significantly attenuated the disease activity index, colitis score, histopathological changes and myeloperoxidase activity. GHP has significant protective effects against DSS induced colitis.

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Authors (7)

Sreeraj Gopi
Augustine Amalraj
Shintu Jude
Karthik Varma
T.r. Sreeraj
Józef Haponiuk prof. dr hab. inż.
Sabu Thomas

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Category:: Articles
Type:: artykuł w czasopiśmie wyróżnionym w JCR
Published in:: Materials Science & Engineering C-Materials for Biological Applications no. 81, pages 20 - 31,
ISSN: 0928-4931
Language:: English
Publication year:: 2017
Bibliographic description:: Gopi S., Amalraj A., Jude S., Varma K., Sreeraj T., Haponiuk J., Thomas S.: Preparation, characterization and anti-colitis activity of curcumin-asafoetida complex encapsulated in turmeric nanofiber// Materials Science & Engineering C-Materials for Biological Applications. -Vol. 81, (2017), s.20-31
DOI:: Digital Object Identifier (open in new tab) 10.1016/j.msec.2017.07.037
Verified by:: Gdańsk University of Technology