Structure-property relationships disclosed in the family of acridinium esters – chemiluminogenic molecules of great practical importance

Karol Krzymiński; Lucyna Holec-Gąsior; Justyna Czechowska-kryszk

Structure-property relationships disclosed in the family of acridinium esters – chemiluminogenic molecules of great practical importance

Abstract

Acridinium esters (AE), since their introduction to the analytics 30 years ago, make one of the most important groups of chemiluminogenic (CL) systems, that have been employed in medical diagnostics and environmental analysis today. So far, however, no systematic studies on the structureproperty relationships were carried out in this family of compounds. The latter features likely determine their practical utility and facilitate rational designing of the new labels and indicators with their use. Investigations, that we were conducting in recent years over those molecular systems enabled us to determine some crucial parameters, influencing luminogenic properties of AEs. The latter problems, together with the examples of our original analytical solutions with the use of selected AEs will be addressed during the presentation. The study involved a wide group of specially developed AEs, their precursors, and the products of their luminogenic ransformations in solutions. The main conclusions of this work,: • Short-range interactions determine the unique crystal structuresof AEs. • AE are thermodynamically stable and durable below 500 K. They can be stored for any length of time at room temperature, if their analytical use is planned. • The efficiency of AEs emission correlate with a variety of physicochemical parameters, among themwith the volume is of the hydration layer of the of leaving group during CL process. • Original analytical tests were developed with the use of new indicators and markers based on AE.

Authors (3)

Karol Krzymiński
- Uniwersytet Gdański, Wydział Chemii Katedra Chemii Fizycznej
Lucyna Holec-Gąsior dr hab. inż.
Justyna Czechowska-kryszk
- Uniwersytet Gdański, Wydział Chemii Katedra Chemii Fizycznej