Synthesis of Novel Polycationic Quaternary Di- and Trispirocyclic Benzenes

Jaroslaw Spychala

doi:https://doi.org/10.1080/00397910500278511

Synthesis of Novel Polycationic Quaternary Di- and Trispirocyclic Benzenes

Abstract

Treatment of hexakis(bromomethyl)benzene with a cyclic amine {morpholine, 1-methylpiperazine, 1-(2-hydroxyethyl)piperazine, isonipecotamide, 4-hydroxypiperidine, 4-[3-(4-piperidyl)propyl]-1-piperidineethanol} gave a range of di- and trispirocyclic ammonium salts in satisfactory yields (22-62%). Presumably, the electrostatic and repulsion forces play an important role in their formation. The structure in soln. and the protonation site were investigated by NMR and IR spectroscopy.

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Jaroslaw Spychala dr

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Category:: Magazine publication
Type:: Magazine publication
Published in:: SYNTHETIC COMMUNICATIONS no. 35, edition 23, pages 2985 - 2992,
ISSN: 0039-7911
Publication year:: 2005
Bibliographic description:: Jaroslaw Spychala, Synthesis of Novel Polycationic Quaternary Di- and Trispirocyclic Benzenes, Synthetic Communications, vol. 35(23), pages 2985-2992, 2005.
DOI:: Digital Object Identifier (open in new tab) https://doi.org/10.1080/00397910500278511
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