Search
Synthesis, spectroscopy and computational studies of some novelphosphorylated derivatives of quinoline-5,8-diones
Abstract
The neutral phosphorus nucleophiles such as R2P(=Y)M allowed the radical addition to 2-methyl-5,8-dioxo-5,8-dihydroquinoline-7-amine and N-(2-methyl-5,8-dioxo-5,8-dihydroquinolin-7-yl)acetamide giving exclusively O-phosphorylated products. All products were quantitatively prepared and characterized by microanalysis, and multinuclear NMR spectroscopy. Seven of them, have been characterized by single crystal X-ray diffraction method. The geometries of the studied compounds were optimized in singlet states using the density functional theory (DFT) method with B3LYP functional.Neutralne fosforowe nukleofile takie jak: R2P(=Y)M pozwalają na rodnikową addycję do 2-metylo-5,8-dioxo-5,8-dihydrochinoliny-7-aminy i N-(2-metylo-5,8-dioxo-5,8-dihydrochinoliny-7-yl)acetamidu dając wyłącznie O-fosforylowane produkty. Wszystkie otrzymane związki były poddane badaniu poprzez mikroanalizę, NMR. Część z nich uzyskano w postaci monokryształów i zmierzono przy pomocy rentgenowskiej analizy strukturalnej. Dodatkowo geometria uzyskanych związków była optymalizowana przy pomocy metod obliczeniowych DFT.
Authors (6)
Cite as
Full text
full text is not available in portal
Keywords
Details
- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
-
JOURNAL OF MOLECULAR STRUCTURE
no. 986,
pages 39 - 48,
ISSN: 0022-2860 - Language:
- English
- Publication year:
- 2011
- Bibliographic description:
- Nycz J., Malecki G., Ponikiewski Ł., Leboschka M., Nowak M., Kusz J.: Synthesis, spectroscopy and computational studies of some novelphosphorylated derivatives of quinoline-5,8-diones// JOURNAL OF MOLECULAR STRUCTURE. -Vol. 986, nr. iss. 1-3 (2011), s.39-48
- Verified by:
- Gdańsk University of Technology
seen 134 times
Recommended for you
Synthesis, spectroscopy and computational studies of some biologically important hydroxyhaloquinolines and their novel derivatives
- G. Małecki,
- J. Nycz,
- E. Ryrych
- + 4 authors