Trimethyl Lock Based Tools for Drug Delivery and Cell Imaging – Synthesis and Properties

Andrzej Stanisław Skwarecki; Joanna Stefaniak-Skorupa; Michał Nowak

doi:10.1002/chem.202403486

Trimethyl Lock Based Tools for Drug Delivery and Cell Imaging – Synthesis and Properties

Abstract

Trimethyl lock (TML) systems have become increasingly important in medicinal and bioorganic chemistry, particularly for their roles in the targeted delivery of therapeutic agents and as integral components in fluorogenic probes for cellular imaging. The simplicity and efficiency of their synthesis have established TML systems as versatile platforms for the controlled release of active molecules under particular physiological conditions. This review consolidates recent advancements in the application of TML systems, with a focus on their use in drug delivery, cellular imaging, and other areas where precise molecular release is crucial. Additionally, we discuss the synthetic strategies employed to construct TML-based conjugates, underscoring their potential to enhance the specificity and efficacy of bioactive compounds in various biomedical applications.

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Authors (3)

Andrzej Stanisław Skwarecki (formerly: Andrzej Skwarecki) dr inż.
Joanna Stefaniak-Skorupa
Michał Nowak
- Laboratory of Polymer Chemistry, Faculty of Science, Universite Libre de Bruxelles

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Articles

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artykuły w czasopismach

Published in:

CHEMISTRY-A EUROPEAN JOURNAL no. 31, pages 1 - 28,
ISSN: 0947-6539

Language:

English

Publication year:

2025

Bibliographic description:

Skwarecki A., Stefaniak-Skorupa J., Nowak M.: Trimethyl Lock Based Tools for Drug Delivery and Cell Imaging – Synthesis and Properties// CHEMISTRY-A EUROPEAN JOURNAL -,iss. 4 (2025), s.1-28

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