Cleavable molecular nanocarrier:antimetabolite conjugates of antimicrobial activity - Project - MOST Wiedzy

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Cleavable molecular nanocarrier:antimetabolite conjugates of antimicrobial activity

This project contains proposal of execution of complex, interdisciplinary studies concerning rational design, synthesis and determination of biological properties of conjugates of molecular nanocarriers with inhibitors of bacterial and fungal enzymes (antimetabolites), containing in their structures linkers cleavable by enzymes present in microbial cells but stable in blood serum. Components of the conjugates will be as follows: cell penetrating peptides, molecular umbrellas and lipidic molecules as molecular nanocarriers, linkers cleavable by esterases and β-glycosidases and inter alia, 5-fluorocytosine and inhibitors of bacterial alanine racemase as antimetabolites. The main goal of the proposed studies is verification of reality and applicability of a novel concept of construction of potential antifungal and antibacterial drugs based on conjugation of effective molecular nanocarriers with antimetabolites through the linkers selectively cleaved in microbial cells. Expected results include: determination of molecular basis and factors determining biological activity of novel conjugates and formulation of guidelines for further optimization of conjugate structures in terms of their penetrability through biological membranes, stability in blood serum and selective toxicity.

Details

Project's funding:
OPUS
Agreement:
UMO-2020/39/B/ST4/01509 z dnia 2021-06-08
Realisation period:
2021-06-08 - 2024-06-07
Project manager:
prof. dr hab. inż. Sławomir Milewski
Team members:
Realised in:
Department of Pharmaceutical Technology and Biochemistry
Request type:
National Research Programmes
Domestic:
Domestic project
Verified by:
Gdańsk University of Technology

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