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Abstract
Conjugates composed of C2-18 fatty acid (FA) residues as a molecular carrier and 5-fluorocytosine (5-FC) as an active agent, released upon the action of intracellular esterases on the ester bond between FA and “trimethyl lock” intramolecular linker, demonstrate good in vitro activity against human pathogenic yeasts of Candida spp. The minimal inhibitory concentrations (MIC) values for the most active conjugates containing caprylic (C8), capric (C10), lauric (C12), or myristic (C14) acid residues were in the 2–64 μg mL.
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- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.ejmech.2023.115293
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- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
no. 252,
ISSN: 0223-5234 - Language:
- English
- Publication year:
- 2023
- Bibliographic description:
- Nowak M., Skwarecki A., Pilch J., Górska J., Szweda P., Milewska M., Milewski S.: Fatty acids as molecular carriers in cleavable antifungal conjugates// EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY -Vol. 252, (2023), s.115293-
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.ejmech.2023.115293
- Sources of funding:
- Verified by:
- Gdańsk University of Technology
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