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Abstract
Structures of several dozen of known antibacterial, antifungal or antiprotozoal agents are based on the amino acid scaffold. In most of them, the amino acid skeleton is of a crucial importance for their antimicrobial activity, since very often they are structural analogs of amino acid intermediates of different microbial biosynthetic pathways. Particularly, some aminophosphonate or aminoboronate analogs of protein amino acids are effective enzyme inhibitors, as structural mimics of tetrahedral transition state intermediates. Synthesis of amino acid antimicrobials is a particular challenge, especially in terms of the need for enantioselective methods, including the asymmetric synthesis. All these issues are addressed in this review, summing up the current state-of-the-art and presenting perspectives fur further progress.
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- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.1002/cmdc.202100503
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- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
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CHEMMEDCHEM
no. 16,
pages 3513 - 3544,
ISSN: 1860-7179 - Language:
- English
- Publication year:
- 2021
- Bibliographic description:
- Nowak M., Skwarecki A., Milewska M.: Amino Acid Based Antimicrobial Agents – Synthesis and Properties// CHEMMEDCHEM -,iss. 16 (2021), s.3513-3544
- DOI:
- Digital Object Identifier (open in new tab) 10.1002/cmdc.202100503
- Sources of funding:
- Verified by:
- Gdańsk University of Technology
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