Unsupervised machine-learning classification of electrophysiologically active electrodes during human cognitive task performance - Publication - Bridge of Knowledge

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Unsupervised machine-learning classification of electrophysiologically active electrodes during human cognitive task performance

Abstract

Identification of active electrodes that record task-relevant neurophysiological activity is needed for clinical and industrial applications as well as for investigating brain functions. We developed an unsupervised, fully automated approach to classify active electrodes showing event-related intracranial EEG (iEEG) responses from 115 patients performing a free recall verbal memory task. Our approach employed new interpretable metrics that quantify spectral characteristics of the normalized iEEG signal based on power-in-band and synchrony measures. Unsupervised clustering of the metrics identified distinct sets of active electrodes across different subjects. In the total population of 11,869 electrodes, our method achieved 97% sensitivity and 92.9% specificity with the most efficient metric. We validated our results with anatomical localization revealing significantly greater distribution of active electrodes in brain regions that support verbal memory processing. We propose our machine-learning framework for objective and efficient classification and interpretation of electrophysiological signals of brain activities supporting memory and cognition.

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Category:
Articles
Type:
artykuły w czasopismach
Published in:
Scientific Reports no. 9, pages 1 - 14,
ISSN: 2045-2322
Language:
English
Publication year:
2019
Bibliographic description:
Saboo K., Varatharajah Y., Berry B., Kremen V., Sperling M., Davis K., Jobst B., Gross R., Lega B., Sheth S., Worrell G., Iyer R., Kucewicz M. T.: Unsupervised machine-learning classification of electrophysiologically active electrodes during human cognitive task performance// Scientific Reports -Vol. 9, (2019), s.1-14
DOI:
Digital Object Identifier (open in new tab) 10.1038/s41598-019-53925-5
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Sources of funding:
Verified by:
Gdańsk University of Technology

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