Search results for: 1,3-DIOXANE-4,6-DIONE

• Mechanism of the Reaction of Amines with 5-[(Aryl- or Alkylamino)hydroxymethylene]-2,2-dimethyl-1,3-dioxane-4,6-diones in the Presence of Chlorotrimethylsilane (Me3SiCl);

  Publication

  • K. Janikowska
  • S. Makowiec
  • J. Rachoń

  - HELVETICA CHIMICA ACTA - Year 2013

  Addition of chlorotrimethylsilane (Me3SiCl) to the mixture of a carbamoyl‐substituted Meldrum's acid, i.e., a 5‐[(arylamino)hydroxymethylene]‐2,2‐dimethyl‐1,3‐dioxane‐4,6‐dione of type 1 and a secondary amine as nucleophile strongly accelerated the rate of their reaction. The reason for this phenomenon observed, during our previous research, remained, however, unclear. To elucidate the mechanism of this reaction, we assumed and...

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• Practical Method for the Preparation of 2,2-Dimethyl-5- {aryl[(hetero)aryl]methyl}-1,3-dioxane-4,6-diones: Synthesis and Mechanistic Study

  Publication

  • E. Najda-Mocarska
  • A. Zakaszewska
  • K. Janikowska
  • S. Makowiec

  - SYNTHESIS-STUTTGART - Year 2016

  An efficient practical synthetic procedure has been developed for the synthesis of 2,2-dimethyl-5-{aryl[(hetero)aryl]methyl}- 1,3-dioxane-4,6-diones through Friedel–Crafts alkylation. The scope and limitation of the reaction of 2,2-dimethyl-5-arylidene-1,3-dioxane- 4,6-diones with π-excess aromatic systems have been delineated.

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• New thiourea organocatalysts and their application for the synthesis of 5-(1H-indol-3-yl)methyl-2,2-dimethyl-1,3-dioxane-4,6-diones a source of chiral 3-indoylmethyl ketenes

  Publication

  • S. Makowiec
  • E. Najda-Mocarska
  • A. Zakaszewska
  • K. Janikowska

  - SYNTHETIC COMMUNICATIONS - Year 2018

  The stereoselective properties of modified thiourea organocatalysts were tested in the Friedel–Crafts alkylation of indole with 5-arylidene-2,2-dimethyl-1,3-dioxane-4,6-diones, which produces chiral 5-((1H-indol-3-yl)(aryl)methyl)-2,2-dimethyl-1,3-dioxane-4,6-diones. Based on a tentative reaction mechanism for ((S)-N-benzyl-2-(3-(3,5-bis (trifluoromethyl)phenyl)thioureido)-N,3,3-trimethylbutanamide organocatalysts, modifications...

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• Krzysztof Jan Kaliński prof. dr hab. inż.

  People

  Institute of Mechanics and Machine Design

  Krzysztof J. Kaliński completed his MSc study at Gdańsk University of Technology (GUT) Faculty of Production Engineering (1980, result – get a first). He obtained PhD at GUT Faculty of Machine Building (1988, result – get a first), DSc at GUT Faculty of Mechanical Engineering (ME) (2002, result – get a first), and professor’s title – w 2013 r. In 2015 r. he became full professor, and since 2019 - professor.His research area includes:...

• Włodzimierz Przybylski prof. dr inż.

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• Krzysztof Nyka dr hab. inż.

  People

  Department of Microwave and Antenna Engineering

  Krzysztof Nyka, received MSc (1986)  PhD (2002) and DSc (2020)  degrees in telecommunication and electrical engineering from the Faculty of Electronics, Telecommunications and Informatics (ETI) of Gdańsk University of Technology (GUT), Poland. He is currently an Associate Professor at the Department of Microwaves and Antenna Engineering, Faculty of ETI, GUT. Before his academic career, he worked for the electronic industry (1984-1986). Research...

• Robert Jankowski prof. dr hab. inż.

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  Doctoral School, Department of Building Engineering

  He was born on December 26, 1968 in Gdynia. A graduate of the High School at the Consulate of Poland in Benghazi, Libya (1987), a student at the Gdańsk University of Technology (MSc studies, 1987-1991 and 1992-1993), University of Sheffield, England (BSc studies, 1991-1992), University of Roskilde, Denmark (MSc course, 1993) and University of Tokyo, Japan (PhD studies, 1994-1997). From the beginning of his professional career associated...

• Elżbieta Cecerska-Heryć dr n.med.

  People

  Wykształcenie i stopnie naukowe: 19.06.2018 r.ukończenie studiów doktoranckich z wyróżnieniem summa cum  laudena Wydziale Lekarskim z OdziałemNauczania w Języku Angielskim PUM SzczecinStopień naukowy: doktor nauk medycznychWyższe2008-2013                               Pomorski Uniwersytet Medyczny w Szczecinie            Kierunek: Biotechnologia            Specjalność: Biotechnologia MedycznaStudia licencjackie i magisterskieZatrudnienie...

• Dariusz Mikielewicz prof. dr hab. inż.

  People

  Zakład Systemów i Urządzeń Energetyki Cieplnej, Gdańsk University of Technology, Faculty of Mechanical Engineering and Ship Technology, Institute of Energy

  Professor Dariusz Mikielewicz – born on February 6, 1967. in Gdansk. Here in 1974 he enrolled first to the Elementary School No. 17, and then in the Grammar School No. 5, named after Stefan Żeromski in Gdansk-Oliwa. After graduating from the Secondary School, with honors, in 1985 he successfully passed the entrance exams to the Faculty of Mechanical Engineering of Technical University of Gdansk, where he graduated with a very good...

• Unusual behavior of secondary amine group as a leaving group

  Publication

  • P. Punda

  - Year 2012

  In our recent project we focused on reactivity of2,2-dimethyl-4,6-dioxane-1,3-dione carbamoilo- and thiocarbamoylo- derivatives as a ketenesource. Meldrum`s acid derivatives after thermal decomposition gives substituted keteneswith stoichiometric yield, that can be trapped with various spectrum of nucleophiles likealcohols, thiols, amine, imines etc. In case of5-[3-(dimethylamino)-sulfanyl-propyliden]-2,2-dimethyl-1,3-dioxane-4,6-dione...