Search results for: electrochemistry mass spectrometry

• Electrochemistry/mass spectrometry (EC/MS) for fast generation and identification of novel reactive metabolites of two unsymmetrical bisacridines with anticancer activity.

  Publication

  • A. Potęga
  • V. Göldner
  • E. Niehaves
  • E. Paluszkiewicz
  • U. Karst

  - JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS - Year 2023

  The development of a new drug requires knowledge about its metabolic fate in a living organism, regarding the comprehensive assessment of both drug therapeutic activity and toxicity profiles. Electrochemistry (EC) coupled with mass spectrometry (MS) is an efficient tool for predicting the phase I metabolism of redox-sensitive drugs. In particular, EC/MS represents a clear advantage for the generation of reactive drug transformation...

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• INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

  Journals

  ISSN: 1387-3806 , eISSN: 1873-2798

• Mass Spectrometry

  Journals

  ISSN: 2187-137X , eISSN: 2186-5116

• Phase I and phase II metabolism simulation of antitumor-active 2-hydroxyacridinone with electrochemistry coupled on-line with mass spectrometry.

  Publication

  • A. Potęga
  • D. Garwolińska
  • A. M. Nowicka
  • M. Fau
  • A. Kot-Wasik
  • Z. Mazerska

  - XENOBIOTICA - Year 2019

  Here, we report the metabolic profile and the results of associated metabolic studies of 2-hydroxyacridinone (2-OH-AC), the reference compound for antitumor-active imidazo- and triazoloacridinones. Electrochemistry coupled with mass spectrometry was applied to simulate the general oxidative metabolism of 2-OH-AC for the first time. The reactivity of 2-OH-AC products to biomolecules was also examined. The usefulness of the electrochemistry...

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• Clinical Mass Spectrometry

  Journals

  eISSN: 2376-9998

• Mass Spectrometry Letters

  Journals

  ISSN: 2233-4203 , eISSN: 2093-8950

• JOURNAL OF MASS SPECTROMETRY

  Journals

  ISSN: 1076-5174 , eISSN: 1096-9888

• EUROPEAN JOURNAL OF MASS SPECTROMETRY

  Journals

  ISSN: 1469-0667 , eISSN: 1751-6838

• Mass Spectrometry-Based Direct Analytical Techniques

  Publication

  • R. Marcinkowska
  • K. Pytel
  • B. Zabiegała

  - Year 2019

  Direct analysis of samples is considered as one of the most environmentally sustainable solutions in analytical chemistry. In the ideal case, such solutions do not require sample preparation and analytes separation steps, therefore do not consumpt harmful substances (or consumpt only minimum amounts of them) and do not generate hazardous waste. Technical solutions for direct analysis also offer miniaturized and field-portable analyzers...

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• Advances in mass spectrometry for iron speciation in plants

  Publication

  • G. AlChoubassi
  • J. Aszyk
  • P. Pisarek
  • K. Bierla
  • L. Ouerdane
  • J. Szpunar
  • R. Łobiński

  - TRAC-TRENDS IN ANALYTICAL CHEMISTRY - Year 2018

  Iron is an important nutrient essential for plants and critical for human health. The state-of-the art of methods for iron speciation in cereal grains and plant fluids is critically reviewed. Particular attention is given to the latest developments in the coupling of HPLC with the parallel ICP MS and electrospray ionization (ESI) MS/MS detection, usually QTOF MS or Q-Orbitrap MS, for the identification and quantification of iron...