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Search results for: CANCER
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Myotilin, a New Topotecan Resistant Protein in Ovarian Cancer Cell Lines
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cDNA sequencing improves the detection of P53 missense mutations in colorectal cancer
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Severe oxidatively damaged DNA after cisplatin treatment of cancer patients
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MC1R common variants, CDKN2A and their association with melanoma and breast cancer risk
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RAGE as a Novel Biomarker for Prostate Cancer: A Systematic Review and Meta-Analysis
PublicationThe receptor for advanced glycation end-products (RAGE) has been implicated in driving prostate cancer (PCa) growth, aggression, and metastasis through the fueling of chronic inflammation in the tumor microenvironment. This systematic review and meta-analysis summarizes and analyzes the current clinical and preclinical data to provide insight into the relationships among RAGE levels and PCa, cancer grade, and molecular effects....
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The rs1447295 and DG8S737 markers on chromosome 8q24 and cancer risk in the Polish population
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H2AX phosphorylation, its role in DNA damage response and cancer therapy
PublicationDouble-strand breaks (DSBs) are the most deleterious DNA lesions, which, if left unrepaired, may have severe consequences for cell survival, as they lead to chromosome aberrations, genomic instability, or cell death. Various physical, chemical, and biological factors are involved in DSB induction. Cells respond to DNA damage by activating the so-called DNA damage response (DDR), a complex molecular mechanism developed to detect...
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Insights into oral microbiome and colorectal cancer – on the way of searching new perspectives
PublicationMicrobiome is a keystone polymicrobial community that coexist with human body in a beneficial relationship. These microorganisms enable the human body to maintain homeostasis and take part in mechanisms of defense against infection and in the absorption of nutrients. Even though microbiome is involved in physiologic processes that are beneficial to host health, it may also cause serious detrimental issues. Additionally, it has been...
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The Influence of Antitumor Unsymmetrical Bisacridines on 3D Cancer Spheroids Growth and Viability
PublicationThe culture of 3D spheroids is a promising tool in drug development and testing. Recently, we synthesized a new group of compounds, unsymmetrical bisacridines (UAs), which exhibit high cytotoxicity against various human cell lines and antitumor potency against several xenografts. Here, we describe the ability of four UAs—C-2028, C-2041, C-2045, and C-2053—to influence the growth of HCT116 and H460 spheres and the viability of HCT116...
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Oxidative DNA damage in cancer patients: a cause or a consequence of the disease development?
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K-ras gene mutation as an early prognostic marker of colon cancer
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The significance of lumican expression in ovarian cancer drug-resistant cell lines
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Diagnostic potential for a serum miRNA neural network for detection of ovarian cancer
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Prognostic factors in postoperative radiotherapy for prostate cancer – tertiary center experience
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Inhibition of protein glycosylation reverses the MDR phenotype of cancer cell lines
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Pharmacokinetics and pharmacodynamics of propofol in cancer patients undergoing major lung surgery
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Urinary metabolomic signature of muscle-invasive bladder cancer: A multiplatform approach
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The usefulness of nasopharyngoscopy in the diagnostics and treatment planning for patients with early glottic cancer
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Radiation-induced injury of the exocrine pancreas after chemoradiotherapy for gastric cancer
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Inhibitory mikrotubul w terapii przeciwnowotworowej = Inhibitors of microtubule in cancer therapy
PublicationW artykule opisano inhibitory mikrotubul, różnorodne związki chemiczne, znajdujące się w zaawansowanych przedklinicznych i wstępnych badaniach klinicznych. Pośród nich na uwagę zasługują półsyntetyczne analogi taksolu, substancje pochodzenia naturalnego, takie jak: epotilony, kombretastatyny, kolchinoidy, dolastatyny oraz syntetyczne związki o niskim ciężarze czasteczkowym: heterokombretastatyny, sulfonamidy, fenostatyny, pochodne...
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Cadmium, arsenic, selenium and iron– Implications for tumor progression in breast cancer
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Metachronous adenocarcinoma in a gastric tube after radical surgery for oesophageal cancer
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A common nonsense mutation of the BLM gene and prostate cancer risk and survival
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Breast Cancer Heterogeneity Investigation: Multiple k-Means Clustering Approach
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Molecular Profiling for Predictors of Radiosensitivity in Patients with Breast or Head-and-Neck Cancer
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Erratum to: Sulforaphane inhibits growth of phenotypically different breast cancer cells
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Radiation-Induced Changes in Serum Lipidome of Head and Neck Cancer Patients
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Mixture model of NMR - its application to diagnosis and treatment of brain cancer
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The Influence of The Light-Activated Titania P25 on Human Breast Cancer Cells
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Expression of Selected Epithelial-Mesenchymal Transition Transcription Factors in Endometrial Cancer
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25(OH)D3 in patients with ovarian cancer and its correlation with survival
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Serum Inhibin A and Inhibin B Levels in Epithelial Ovarian Cancer Patients
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Serum Anti-Müllerian Hormone Levels in Patients with Epithelial Ovarian Cancer
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Are antioxidant enzymes essential markers in the diagnosis and monitoring of cancer patients – A review
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Quality of life in long-term survivors of early stage endometrial cancer
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Clinical Implications of mTOR Expression in Papillary Thyroid Cancer—A Systematic Review
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Influence of Transurethral Resection of Bladder Cancer on Sexual Function, Anxiety, and Depression
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New data on antihypertensive drugs and risk of cancer: should we worry?
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Differential Response of MDA-MB-231 and MCF-7 Breast Cancer Cells to In Vitro Inhibition with CTLA-4 and PD-1 through Cancer-Immune Cells Modified Interactions
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Can popular films instil carcinophobia? Images of cancer in popular Polish cinema
PublicationIntroduction: Although cancer is currently considered a serious socio-medical challenge and health education in Poland has been positioned as a public health priority, the impact of popular culture on people’s ideas about cancer has been neglected. This study therefore aims to analyse the way popular Polish films portray cancer and the experience of cancer.Material and Methods: Seven popular Polish films featuring cancer...
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Deep Learning-Based, Multiclass Approach to Cancer Classification on Liquid Biopsy Data
PublicationThe field of cancer diagnostics has been revolutionized by liquid biopsies, which offer a bridge between laboratory research and clinical settings. These tests are less invasive than traditional biopsies and more convenient than routine imaging methods. Liquid biopsies allow studying of tumor-derived markers in bodily fluids, enabling the development of more precise cancer diagnostic tests for screening, disease monitoring, and...
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Caffeine Inhibits Differentiation Of Lung Cancer Stem Cells By Modulating Their Respiratory Metabolism
PublicationIt is ell established that many tumor types contain a fraction of cells, with stem cell-like properties, called cancer stem cells (CSCs), that are resistant to apoptosis induced by therapeutic agents. The presence of CSCs may explain why a standard anticancer treatment, that eliminates only differentiated cancer cells, does not lead to cancer cure.We previously showed the existence of caffeine-sensitive mechanism that controls...
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Environmental exposure to cadmium in breast cancer – association with the Warburg effect and sensitivity to tamoxifen
PublicationThe association between cadmium and breast cancer remains unexplained due to inconsistent epidemiological data and unknown underlying mechanisms. This study aimed to assess the relationship between environmental exposure to cadmium and the Warburg effect in breast cancer and, thus, its possible interference with breast cancer treatment. The observational study in two groups of breast cancer patients indicated a positive correlation between...
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Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition
PublicationHeterocyclic pharmacophores such as thiazole and quinoline rings have a significant role in medicinal chemistry. They are considered privileged structures since they constitute several Food and Drug Administration (FDA)-approved drugs for cancer treatment. Herein, we report the synthesis, in silico evaluation of the ADMET profiles, and in vitro investigation of the anticancer activity of a series of novel thiazolyl-hydrazones based...
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CDKN2A common variant and multi-organ cancer risk—a population-based study
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Germline mutations in theCHEK2 kinase gene are associated with an increased risk of bladder cancer
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A personalised approach to prostate cancer screening based on genotyping of risk founder alleles
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314 Osteopontin as a Potential Serum Marker in Early Breast Cancer-Preliminary Results
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Melanoma skin cancer detection using mask-RCNN with modified GRU model
PublicationIntroduction: Melanoma Skin Cancer (MSC) is a type of cancer in the human body; therefore, early disease diagnosis is essential for reducing the mortality rate. However, dermoscopic image analysis poses challenges due to factors such as color illumination, light reflections, and the varying sizes and shapes of lesions. To overcome these challenges, an automated framework is proposed in this manuscript. Methods: Initially, dermoscopic...
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Determination of amino acids in urine of patients with prostate cancer and benign prostate growth
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