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Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition
PublicationHeterocyclic pharmacophores such as thiazole and quinoline rings have a significant role in medicinal chemistry. They are considered privileged structures since they constitute several Food and Drug Administration (FDA)-approved drugs for cancer treatment. Herein, we report the synthesis, in silico evaluation of the ADMET profiles, and in vitro investigation of the anticancer activity of a series of novel thiazolyl-hydrazones based...
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Environmental exposure to cadmium in breast cancer – association with the Warburg effect and sensitivity to tamoxifen
PublicationThe association between cadmium and breast cancer remains unexplained due to inconsistent epidemiological data and unknown underlying mechanisms. This study aimed to assess the relationship between environmental exposure to cadmium and the Warburg effect in breast cancer and, thus, its possible interference with breast cancer treatment. The observational study in two groups of breast cancer patients indicated a positive correlation between...
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Method-Dependent Epidemiological Cutoff Values for Detection of Triazole Resistance in Candida and Aspergillus Species for the Sensititre YeastOne Colorimetric Broth and Etest Agar Diffusion Methods
PublicationAlthough the Sensititre Yeast-One (SYO) and Etest methods are widely utilized, interpretive criteria are not available for triazole susceptibility testing of Candida or Aspergillus species. We collected fluconazole, itraconazole, posaconazole, and voriconazole SYO and Etest MICs from 39 laboratories representing all continents for (method/agent-dependent) 11,171 Candida albicans, 215 C. dubliniensis, 4,418 C. glabrata species complex,...
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Fluconazole resistant Candida auris clinical isolates have increased levels of cell wall chitin and increased susceptibility to a glucosamine-6-phosphate synthase inhibitor
PublicationIn 2009 Candida auris was first isolated as fungal pathogen of human disease from ear canal of a patient in Japan. In less than a decade, this pathogen has rapidly spread around the world and has now become a major health challenge that is of particular concern because many strains are resistant to multiple class of antifungal drugs. The lack of available antifungals and rapid increase of this fungal pathogen provides an incentive...
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Quasistatic and fatigue behavior of an AISI H13 steel obtained by additive manufacturing and conventional method
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Radiation Therapy–Related Changes in Serum Proteome and Lipidome Are Primarily Associated With a Type of Acute Toxicity: Comparison of Radiation-Induced Effects in Patients Treated Because of Head and Neck Cancer or Prostate Cancer
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Human UDP-Glucuronosyltransferases: Effects of altered expression in breast and pancreatic cancer cell lines.
PublicationIncreased aerobic glycolysis and de novo lipid biosynthesis are common characteristics of invasive cancers. UDP-glucuronosyltransferases (UGTs) are phase II drug metabolizing enzymes that in normal cells possess the ability to glucuronidate these lipids and speed their excretion; however, de-regulation of these enzymes in cancer cells can lead to an accumulation of bioactive lipids, which further fuels cancer progression. We hypothesize...
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Structural and physico-mechanical properties of natural rubber/GTR composites devulcanized by microwaves: Influence of GTR source and irradiation time
PublicationGround tire rubber from car and truck was modified using microwave irradiation at variable time. The irradiated ground tire rubber was used as filler in composites based on natural rubber. The composites, with high content of ground tire rubber, were prepared using an internal batch mixer and subsequently cross-linked at 160℃. The influence of the ground tire rubber source (car/truck) and irradiation time on structure, physico-mechanical...
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Bimodal Nd-Doped LuVO4 Nanoprobes Functionalized with Polyacrilic Acid for X-Ray Computed Tomography and NIR Luminescent Imaging
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Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study
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Amplification of erbB-4 oncogene occurs less frequently than that of erbB-2 in primary human breast cancer1Published in conjunction with A Wisconsin Gathering Honoring Waclaw Szybalski on the occasion of his 75th year and 20 years of Editorship-in-Chief of Gene, 10–11 August, 1997, University of Wisconsin, Madison, WI, USA.1
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Histological Features of Neovaginal Epithelium after Vaginoplasty in Mayer-Rokitansky-Küster-Hauser Syndrome
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Rare extragenital endometriosis: pathogenesis and therapy
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Menopause: a trigger for simultaneous development of ulcerative colitis in sigmoid neovagina and residual colorectum?
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Rectovesical ligament in didelphyc uterus: how frequent is it and what does it mean?
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Long-Term Follow-Up after Laparoscopic Uterovestibular Anastomosis in Patients with Cervical Atresia and Complete Absence of the Vagina
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Conservative surgical repair in cervical atresia associated with partial or complete absence of the vagina
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Forty‐two normomenstruating adolescents with Müllerian obstructive anomalies: Presentation, pitfalls in the dagnosis and surgical management
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CUAJ-Canadian Urological Association Journal
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CANADIAN JOURNAL OF DIETETIC PRACTICE AND RESEARCH
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CANADIAN JOURNAL OF FISHERIES AND AQUATIC SCIENCES
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CANADIAN JOURNAL OF CRIMINOLOGY AND CRIMINAL JUSTICE
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Global Media Journal-Canadian Edition
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Journal of the Canadian Health Libraries Association
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Canadian Journal for the Scholarship of Teaching and Learning
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Canadian Society of Forensic Science Journal
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Canadian Graduate Journal of Sociology and Criminology
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Canadian Journal for the Study of Adult Education
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Canadian Journal American and Caribbean Studies
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TOPIA-Canadian Journal of Cultural Studies
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CANADIAN JOURNAL OF ANALYTICAL SCIENCES AND SPECTROSCOPY
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Canadian Journal of Educational Administration and Policy
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Symposium-Canadian Journal of Continental Philosophy
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The Canadian journal of critical care nursing
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CUAJ-Canadian Urological Association Journal
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Canadian Journal of Community Mental Health
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Canadian Journal of Kidney Health and Disease
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Canadian Journal of European and Russian Studies
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TRANSACTIONS OF THE CANADIAN SOCIETY FOR MECHANICAL ENGINEERING
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Maghreb Littéraire (Le). Revue canadienne de littérature magrébine
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Prognostic Value of TOP2A Gene Amplification and Chromosome 17 Polysomy in Early Breast Cancer
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Aggressive Phenotype of Cells Disseminated via Hematogenous and Lymphatic Route in Breast Cancer Patients
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Lipid mediators involved in the oxidative stress and antioxidant defence of human lung cancer cells
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Serum lipid profile discriminates patients with early lung cancer from healthy controls
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Rapana thomasiana hemocyanin modified with ionic liquids with enhanced anti breast cancer activity
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Sulforaphene, an isothiocyanate present in radish plants, inhibits proliferation of human breast cancer cells
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Identification of serum proteome signatures of locally advanced and metastatic gastric cancer: a pilot study
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Microneedle‐Based Generation of Microbubbles in Cancer Tumors to Improve Ultrasound‐Assisted Drug Delivery
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Carbon nanotube based dielectric spectroscopy of tumor secretion; electrochemical lipidomics for cancer diagnosis
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Altered levels of nucleoside metabolite profiles in urogenital tract cancer measured by capillary electrophoresis
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