Search results for: XENOBIOTICS

• Electrochemical simulation of enzymatic transformations studied for the selected antitumor acridine derivatives

  Publication

  • A. Potęga
  • W. Hewelt-Belka
  • O. Siewruk
  • K. Zapała
  • Z. Mazerska

  - Year 2014

  The elucidation of the metabolic pathways and the biotransformation mechanisms of potential drugs is a crucial point in drug development. It allows to know the activation routes of the new biologically active compounds, especially in respect to their possible toxicity. Generally, in vivo or in vitro experiments with liver microsomes or hepatocytes are performed. However, these testing schemes are tedious, time consuming and of...