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• Radiosensitization of DNA in presence of Pt(II)-based compounds

  Publication

  • M. Śmiałek-Telega
  • S. Ptasińska
  • J. Gow
  • C. Da Pieve
  • N. J. Mason

  - EUROPEAN PHYSICAL JOURNAL D - Year 2014

  X-ray irradiation of plasmid DNA in presence of platinum (II)-based compounds was carried out in order to assess the radiosensitization capabilities of these drugs. In present investigations pBR322 plasmid DNA was used to monitor the effectiveness of chosen compounds in inducing strand breaks. Samples were incubated in the presence of potential radiosensitisers: platinum (II) bromide and cis-diamminedibromoplatinum (II). The results...

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