Filters
total: 894
Search results for: DRUG DELIVERY NANOSYSTEM
-
Interactions of dissolved dsDNA with intercalating drug by anodic voltammetry and spectroscopy. Influence of pH
PublicationOddziaływanie związku przeciwnowotworowego C-1305 z DNA było badane przy pomocy impulsowej voltametrii różnicowej oraz spektroskopii UV/Vis. Triazoloakrydon C-1305 oddziałuje z DNA na dwóch drogach: przez interkalacje pomiedzy pary zasad oraz przez wiązanie sie w małym rowku helisy. W fizjologicznym pH (7,4) stałe wiązania wynoszą: K1=3,36E+5 i K2=0,18E+5 [1/M] a wielkość miejsca wiązania: n1=2,5 i n2=4,0, odpowiednio dla pierwszego...
-
Molecular mechanism of the enzymatic oxidation investigated for imidazoacridinone antitumor drug C-1311.
PublicationPraca miala na celu określenie molekularnego mechanizmu enzymatycznej utleniającej aktywacji wymienionego związku przeciwnowotworowego w takim układzie modelowym, w którym wcześniej wykazano jego kowalencyjne wiązanie się do DNA. Badania struktur chemicznych produktów enzymatycznej aktywacji wykazały, że dwa z nich powstają w wyniku dealkilacji łańcucha bocznego cząsteczki, natomiast dwa inne w wyniku aktywacji pierścienia imidazoakrydonu....
-
Batracylina (BAT) - potencjalny lek przeciwnowotworowy. Batracylin (BAT) - potential of anticancer drug
PublicationOpisano działanie potencjalnego leku przeciwnowotworowego - batracyliny(BAT). Batracylina została wyselekcjonowana przez National Cancer Institute (NCI, Bethesda, USA) w 1978 roku jako efekt programu poszukiwań nowych leków chemioterapii.Związek ten w badaniach in vivo u myszy okazał się bardzo aktywny przeciw nowotworowi okrężnicy 38 (colon 38), trudnemu do wyleczenia przez znane leki przeciwnowotworowe. Okazała się ona skuteczna...
-
Regenerative Drug Discovery Using Ear Pinna Punch Wound Model in Mice
PublicationThe ear pinna is a complex tissue consisting of the dermis, cartilage, muscles, vessels, and nerves. Ear pinna healing is a model of regeneration in mammals. In some mammals, including rabbits, punch wounds in the ear pinna close spontaneously; in common-use laboratory mice, they remain for life. Agents inducing ear pinna healing are potential regenerative drugs. We tested the effects of selected bioactive agents on 2 mm ear pinna...
-
Optimizing Last-Mile Delivery: A Multi-Criteria Approach with Automated Smart Lockers, Capillary Distribution and Crowdshipping
Publication -
Spliced analogues of trypsin inhibitor SFTI‐1 and their application for tracing proteolysis and delivery of cargos inside the cells
Publication -
A Decade of Wishes-Changes in Maternal Preference of the Mode of Delivery among Polish Women over the Last Decade
Publication -
A Method for the Evaluation of Urban Freight Transport Models as a Tool for Improving the Delivery of Sustainable Urban Transport Policy
PublicationThe article presents a method which helps local authorities to evaluate urban freight transport models. Given the complex requirements for input data and the inability to supply them for most cities, a proper quantitative evaluation of model functionality may be quite difficult for local authorities. Freight transport models designed to support sustainable urban freight transport objectives are a particular example. To overcome...
-
Trans-endocardial delivery of progenitor cells to compromised myocardium using the “needle technique”and risk of myocardial injury
Publication -
Intercalation complex of imidazoacridinone C-1311, a potential anticancer drug, with DNA helix d(CGATCG)2: stereostructural studies by 2D NMR spectroscopy.
PublicationImidazoacridinone C-1311 (Symadex®) is a powerful antitumor agent, which successfully made its way through the Phase I clinical trials and has been recommended for Phase II few a years ago. It has been shown experimentally that during the initial stage of its action C-1311 forms a relatively stable intercalation complex with DNA, yet it has shown no base-sequence specificity while binding to DNA. In this paper, the d(CGATCG)2:C-1311...
-
New Life of an Old Drug: Caffeine as a Modulator of Antibacterial Activity of Commonly Used Antibiotics
Publication -
The Current Use of Mass Spectrometry in Combination with Other Separation Techniques in Drug Discovery Arena
Publication -
Drug-Releasing Antibacterial Coating Made from Nano-Hydroxyapatite Using the Sonocoating Method
Publication -
Cisplatin filled multiwalled carbon nanotubes – a novel molecular hybrid of anticancer drug container
Publication -
Drug transporter expression profiling in chemoresistant variants of the A2780 ovarian cancer cell line
Publication -
The modulatory effect of green tea catechin on drug resistance in human ovarian cancer cells
Publication -
Acinetobacter baumannii isolated from hospital‐acquired infection: biofilm production and drug susceptibility
Publication -
Fulminant hepatic failure in woman with iron and non-steroidal anti-inflammatory drug intoxication
Publication -
Glucosamine-6-phosphate synthase,a novel target for antifungalagents.Molecular modelling studies in drug design
PublicationPraca dotyczy modelowania zarówno samych inhibitorów syntazy glukozamino-6-fosforanu jak i ich oddziaływania z obydwiema domenami tego enzymu. Enzym syntaza glukozamino-6-fosforanu został zaproponowany jako nowy cel molekularny w chemoterapii infekcji grzybowych. Zaprojektowano i zsyntezowano szereg inhibitorów tego enzymu - potencjalnych nowych leków przeciwgrzybowych. Dzięki modelowaniu molekularnemu udało się wyjaśnić mechanizm...
-
Homoisocitrate dehydrogenase from Candida albicans: properties, inhibition, and targeting by an antifungal pro-drug
PublicationThe LYS12 gene from Candida albicans, coding for homoisocitrate dehydrogenase was cloned and expressed as a His-tagged protein in Escherichia coli. The purified gene product catalyzes the Mg2+- and K+-dependent oxidative decarboxylation of homoisocitrate to alpha-ketoadipate. The recombinant enzyme demonstrates strict specificity for homoisocitrate. SDS-PAGE of CaHIcDH revealed its molecular mass of 42.6±1 kDa, while in size-exclusion...
-
Hydrogel Delivery System Containing Calendulae flos Lyophilized Extract with Chitosan as a Supporting Strategy for Wound Healing Applications
Publication -
Twenty‐four‐hour and conventional blood pressure components and risk of preterm delivery or neonatal complications in gestational hypertension
Publication -
Correction to “Emerging Anticancer Activity of Candidal Glucosamine-6-Phosphate Synthase Inhibitors upon Nanoparticle-Mediated Delivery”
Publication -
DRUG AND CHEMICAL TOXICOLOGY
Journals -
DRUG METABOLISM AND DISPOSITION
Journals -
DRUG DEVELOPMENT RESEARCH
Journals -
DRUG METABOLISM REVIEWS
Journals -
ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES
Journals -
ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
Journals -
Expert Opinion On Drug Safety
Journals -
American Health and Drug Benefits
Journals -
Journal of Drug Metabolism & Toxicology
Journals -
International Journal of Drug Discovery
Journals -
Expert Opinion on Drug Discovery
Journals -
FOOD AND DRUG LAW JOURNAL
Journals -
Drug Healthcare and Patient Safety
Journals -
Clinical Pharmacology in Drug Development
Journals -
INTERNATIONAL JOURNAL OF DRUG POLICY
Journals -
Journal of Drug Policy Analysis
Journals -
Current drug abuse reviews
Journals -
Infectious Disorders - Drug Targets
Journals -
Drug Discovery Today: Technologies
Journals -
Therapeutic Advances in Drug Safety
Journals -
Adverse Drug Reaction Bulletin
Journals -
Current Drug Discovery Technologies
Journals -
Drug Safety - Case Reports
Journals -
Journal of Alcohol and Drug Education
Journals -
Journal of Drug and Alcohol Research
Journals -
Drug Metabolism and Personalized Therapy
Journals -
Adverse Drug Reactions Journal
Journals