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Search results for: POCHODNA 4-METYLO-1-NITROAKRYDYNY C-1748
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Techniki informacyjne w zarządzaniu produkcją , w/c/p, ZiIP, SC, 1.st., sem. 6, letni 2023/2024, (PG_00055257)
e-Learning Courses -
Acridinone antitumor agents: C-1311, C-1330 and C-1305 are metabolized by flavin-containing monooxygenase isoenzymes: FMO1, FMO3 and FMO5 with different rates
PublicationRekombinantowe ludzkie monooksygenazy flawinowe: FMO1, FMO3, FMO5 indukują przemiany metaboliczne wybranych do badań pochodnych akrydonu. Biotransformacja związków C-1311, C-1330 i C-1305 przez FMO prowadzi do jednego produktu o strukturze N-tlenku. Wyniki badań wskazują, że najbardziej podatna na przemiany wobec FMO jest pochodna triazoloakrydonu C-1305. Wydaje się więc, że głównymi enzymami pierwszej fazy przemian metabolicznych...
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Witold Zbirohowski-Kościa, WZiE, 3 i 4 semestralne studia, II st, 1 sem, 20/21l
e-Learning Courses -
Stefan Niewitecki dr inż. arch.
PeopleW dniu 29.07.1977 r. ukończenie Studium Podyplomowego Kształcenia Pedagogicznego Nauczycieli Akademickich (świadectwo Nr 301, wynik dobry). Dnia 29.04.1982 r. nagroda III stopnia Rektora Politechniki Gdańskiej, zespołowa za ''Studium wpływu ujęcia wody Gdańsk-Lipce na stateczność obiektów budowlanych w rejonie leja depresyjnego.'' W 1986 r. nagroda Rektora Politechniki Gdańskiej za ''Orzeczenie i projekt techniczny wzmocnienia...
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Description of symmetrical prolate ellipsoid magnetic signature parameters-Be = 50 mT, I = 70 deg, z = 100 m, q = 80 deg, j = 135 deg, a =4 m, e = 1, mr = 100
Open Research DataThe Earth magnetic field (Fig.1): BE – total magnetic flux density, BEx – x component of the Earth magnetic flux density, BEy = 0 y component of the Earth magnetic flux density, BEz – z component of the Earth magnetic flux density, I – inclination of the Earth magnetic field.
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Description of symmetrical prolate ellipsoid magnetic signature parameters-Be = 50 mT, I = 70 deg, z = 10 m, q = 90 deg, j = 135 deg, a =4 m, e = 1, mr = 100
Open Research DataThe Earth magnetic field (Fig.1): BE – total magnetic flux density, BEx – x component of the Earth magnetic flux density, BEy = 0 y component of the Earth magnetic flux density, BEz – z component of the Earth magnetic flux density, I – inclination of the Earth magnetic field.
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Description of symmetrical prolate ellipsoid magnetic signature parameters-Be = 50 mT, I = 70 deg, z = 100 m, q = 90 deg, j = 135 deg, a =4 m, e = 1, mr = 100
Open Research DataThe Earth magnetic field (Fig.1): BE – total magnetic flux density, BEx – x component of the Earth magnetic flux density, BEy = 0 y component of the Earth magnetic flux density, BEz – z component of the Earth magnetic flux density, I – inclination of the Earth magnetic field.
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Description of symmetrical prolate ellipsoid magnetic signature parameters-Be = 50 mT, I = 70 deg, z = 50 m, q = 80 deg, j = 135 deg, a =4 m, e = 1, mr = 100
Open Research DataThe Earth magnetic field (Fig.1): BE – total magnetic flux density, BEx – x component of the Earth magnetic flux density, BEy = 0 y component of the Earth magnetic flux density, BEz – z component of the Earth magnetic flux density, I – inclination of the Earth magnetic field.
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Description of symmetrical prolate ellipsoid magnetic signature parameters-Be = 50 mT, I = 70 deg, z = 50 m, q = 90 deg, j = 135 deg, a =4 m, e = 1, mr = 100
Open Research DataThe Earth magnetic field (Fig.1): BE – total magnetic flux density, BEx – x component of the Earth magnetic flux density, BEy = 0 y component of the Earth magnetic flux density, BEz – z component of the Earth magnetic flux density, I – inclination of the Earth magnetic field.
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Description of symmetrical prolate ellipsoid magnetic signature parameters-Be = 50 mT, I = 70 deg, z = 20 m, q = 80 deg, j = 135 deg, a =4 m, e = 1, mr = 100
Open Research DataThe Earth magnetic field (Fig.1): BE – total magnetic flux density, BEx – x component of the Earth magnetic flux density, BEy = 0 y component of the Earth magnetic flux density, BEz – z component of the Earth magnetic flux density, I – inclination of the Earth magnetic field.
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Description of symmetrical prolate ellipsoid magnetic signature parameters-Be = 50 mT, I = 70 deg, z = 10 m, q = 80 deg, j = 135 deg, a =4 m, e = 1, mr = 100
Open Research DataThe Earth magnetic field (Fig.1): BE – total magnetic flux density, BEx – x component of the Earth magnetic flux density, BEy = 0 y component of the Earth magnetic flux density, BEz – z component of the Earth magnetic flux density, I – inclination of the Earth magnetic field.
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Description of symmetrical prolate ellipsoid magnetic signature parameters-Be = 50 mT, I = 70 deg, z = 20 m, q = 90 deg, j = 135 deg, a =4 m, e = 1, mr = 100
Open Research DataThe Earth magnetic field (Fig.1): BE – total magnetic flux density, BEx – x component of the Earth magnetic flux density, BEy = 0 y component of the Earth magnetic flux density, BEz – z component of the Earth magnetic flux density, I – inclination of the Earth magnetic field.
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Description of symmetrical prolate ellipsoid magnetic signature parameters-Be = 50 mT, I = 70 deg, z = 200 m, q = 80 deg, j = 135 deg, a =4 m, e = 1, mr = 100
Open Research DataThe Earth magnetic field (Fig.1): BE – total magnetic flux density, BEx – x component of the Earth magnetic flux density, BEy = 0 y component of the Earth magnetic flux density, BEz – z component of the Earth magnetic flux density, I – inclination of the Earth magnetic field.
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Description of symmetrical prolate ellipsoid magnetic signature parameters-Be = 50 mT, I = 70 deg, z = 200 m, q = 90 deg, j = 135 deg, a =4 m, e = 1, mr = 100
Open Research DataThe Earth magnetic field (Fig.1): BE – total magnetic flux density, BEx – x component of the Earth magnetic flux density, BEy = 0 y component of the Earth magnetic flux density, BEz – z component of the Earth magnetic flux density, I – inclination of the Earth magnetic field.
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Description of symmetrical prolate ellipsoid magnetic signature parameters-Be = 50 mT, I = 70 deg, z = 100 m, q = 90 deg, j = 135 deg, a =4 m, e = 1, mr = 100
Open Research DataThe Earth magnetic field (Fig.1): BE – total magnetic flux density, BEx – x component of the Earth magnetic flux density, BEy = 0 y component of the Earth magnetic flux density, BEz – z component of the Earth magnetic flux density, I – the inclination of the Earth magnetic field.
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Description of symmetrical prolate ellipsoid magnetic signature parameters-Be = 50 mT, I = 70 deg, z = 200 m, q = 90 deg, j = 45 deg, a =4 m, e = 1, mr = 100
Open Research DataThe Earth magnetic field (Fig.1): BE – total magnetic flux density, BEx – x component of the Earth magnetic flux density, BEy = 0 y component of the Earth magnetic flux density, BEz – z component of the Earth magnetic flux density, I – the inclination of the Earth magnetic field.
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Description of symmetrical prolate ellipsoid magnetic signature parameters-Be = 50 mT, I = 70 deg, z = 10 m, q = 90 deg, j = 90 deg, a =4 m, e = 1, mr = 100
Open Research DataThe Earth magnetic field (Fig.1): BE – total magnetic flux density, BEx – x component of the Earth magnetic flux density, BEy = 0 y component of the Earth magnetic flux density, BEz – z component of the Earth magnetic flux density, I – the inclination of the Earth magnetic field.
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Description of symmetrical prolate ellipsoid magnetic signature parameters-Be = 50 mT, I = 70 deg, z = 20 m, q = 90 deg, j = 135 deg, a =4 m, e = 1, mr = 100
Open Research DataThe Earth magnetic field (Fig.1): BE – total magnetic flux density, BEx – x component of the Earth magnetic flux density, BEy = 0 y component of the Earth magnetic flux density, BEz – z component of the Earth magnetic flux density, I – the inclination of the Earth magnetic field.
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Description of symmetrical prolate ellipsoid magnetic signature parameters-Be = 50 mT, I = 70 deg, z = 50 m, q = 90 deg, j = 45 deg, a =4 m, e = 1, mr = 100
Open Research DataThe Earth magnetic field (Fig.1): BE – total magnetic flux density, BEx – x component of the Earth magnetic flux density, BEy = 0 y component of the Earth magnetic flux density, BEz – z component of the Earth magnetic flux density, I – the inclination of the Earth magnetic field.
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Interaction of antitumor triazoloacridone C-1305 and its analogs with telomeric DNA
PublicationBadaliśmy oddziaływanie pochodnej triazoloakrydonu C-1305 i jego bliskich analogów strukturalnych z oligonukleotydami zawierającycmi sekwencje telomerowe TTAGGG oraz oligonukleotydami sfałdowanymi w strukturę G-kwadrupleksu. Wykazaliśmy, że spośród badanych związków pochodna C-1305 wykazała największą specyficzność w stosunku do telomerowego DNA. Związek ten stabilizował także strukturę G-kwadrupleksu, podczas gdy jego analogi...
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The electronic excited states of dichloromethane in the 5.8-10.8 eV energy range investigated by experimental and theoretical methods
PublicationWe present a comprehensive experimental high-resolution vacuum ultraviolet (VUV) photoabsorption spectrum of dichloromethane, CH 2 Cl 2 , with absolute cross sections determined for the full 5.8–10.8 eV energy-range. The calculations on the vertical excitation energies and oscillator strengths were performed using the equation-of-motion coupled cluster method, restricted to the single and double excitations level (EOM-CCSD), and...
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Przemiany metaboliczne in vitro niesymetrycznych bisakrydyn w układach bezkomórkowych i w komórkach nowotworowych oraz określenie wpływu tych pochodnych na aktywność enzymów metabolizujących leki
PublicationPrzedmiotem badań prowadzonych w ramach niniejszej pracy doktorskiej są cztery niesymetryczne bisakrydyny: C-2028, C-2041, C-2045 i C-2053, wykazujące wysoką aktywność cytotoksyczną [Konopa i in. 2019]. Otrzymane wyniki wskazały, że każdy z pierścieni (imidazoakrydonu i 1-nitroakrydyny) obecny w strukturze badanych związków odgrywa inną rolę w wykazywanych przez nie właściwościach fizykochemicznych i biologicznych. Właściwości...
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Mechanical Strength of MV Ship-switchgear During Fault Arc
PublicationIn the paper the analysis of pressure stressed in enclosure during fault arc inside switchgear is pre-sented as well. There is introduced the method based on determining stresses which are sum of tensile stresses (membrane) and deflection stresses. For tensile stresses nalysis the energy method, for unrestrainedly supported rectangular plate, was used. In the further part of the paper, the calculations and measurements results...
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Witold Zbirohowski-Kościa, WZiE, 3 i 4 semestralne studia niest. II st. 1 sem 22/23z
e-Learning Courses -
Inżynieria drogowo-kolejowa w praktyce (WILiŚ, budown. / stacj. / 1 st. / sem. 4 / mod. HandsOnEngineering) - 2023/2024
e-Learning CoursesKurs jest przeznaczony dla studentów Budownictwa, II stopień studiów, semestr 3, którzy jako przedmiot obieralny wybrali "Zarządzanie zasobami drogowymi" w roku akademickim 2022/2023.
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Inżynieria drogowo-kolejowa w praktyce (WILiŚ, budown. / stacj. / 1 st. / sem. 4 / mod. HandsOnEngineering) - 2023/2024
e-Learning CoursesKurs jest przeznaczony dla studentów Budownictwa, II stopień studiów, semestr 3, którzy jako przedmiot obieralny wybrali "Zarządzanie zasobami drogowymi" w roku akademickim 2022/2023.
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Electrochemical simulation of enzymatic transformations studied for the selected antitumor acridine derivatives
PublicationThe elucidation of the metabolic pathways and the biotransformation mechanisms of potential drugs is a crucial point in drug development. It allows to know the activation routes of the new biologically active compounds, especially in respect to their possible toxicity. Generally, in vivo or in vitro experiments with liver microsomes or hepatocytes are performed. However, these testing schemes are tedious, time consuming and of...
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On the derivatives $\partial^{2}P_{\nu}(z)/\partial\nu^{2}$ and $\partial Q_{\nu}(z)/\partial\nu$ of the Legendre functions with respect to their degrees
PublicationWe provide closed-form expressions for the degree-derivatives $[\partial^{2}P_{\nu}(z)/\partial\nu^{2}]_{\nu=n}$ and $[\partial Q_{\nu}(z)/\partial\nu]_{\nu=n}$, with $z\in\mathbb{C}$ and $n\in\mathbb{N}_{0}$, where $P_{\nu}(z)$ and $Q_{\nu}(z)$ are the Legendre functions of the first and the second kind, respectively. For $[\partial^{2}P_{\nu}(z)/\partial\nu^{2}]_{\nu=n}$, we find that % \begin{displaymath} \frac{\partial^{2}P_{\nu}(z)}{\partial\nu^{2}}\bigg|_{\nu=n} =-2P_{n}(z)\Li_{2}\frac{1-z}{2}+B_{n}(z)\ln\frac{z+1}{2}+C_{n}(z), \end{displaymath} % where...
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Energy policy and the role of bioenergy in Poland
PublicationPrzedstawiono sytuacje energetyczną kraju. Omówiono poszczególne sektory wytwarzania energii oraz zapotrzebowania na energię i paliwa. Omówiono przekształcenia sektorów energetycznych w Polsce na przestrzeni lat 1990-2002. Na tym tle przedstawiono techniczne, ekonomiczne, społeczne i prawne aspekty rozwoju energetyki źródeł odnawialnych a w szczególności opartych o bioenergię. Przedstawiono wnioski dla Polski płynące z dotychczasowych...
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Sequential induction of mitotic catastrophe followed by apoptosis in human leukemia MOLT4 cells by imidazoacridinone C-1311
PublicationWykazano, że pochodna imidazoakrydonu C-1311 indukuje zahamowanie progresji komórek MOLT4 w fazie G2M cyklu życiowego. Podwyższona ekspresja fosfoepitopu MPM-2 przy jednoczesnym zaniku ufosforylowanej formy Tyr15-cdc2 wskazywała, iż komórki początkowo zablokowane w fazie G2 przechodziły do mitozy. Jednocześnie na skutek nieprawidłowego przebiegu mitozy komórki ulegały katastrofie mitotycznej. Analiza biochenicznych markerów apoptozy...
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High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [5040730028006171]
Open Research DataThis is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [5040730028004431]
Open Research DataThis is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [5040730028005611]
Open Research DataThis is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [5040730028003681]
Open Research DataThis is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [5040730028001151]
Open Research DataThis is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [5040730028002671]
Open Research DataThis is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [704034723256111]
Open Research DataThis is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [504073002800551]
Open Research DataThis is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Sztuczna inteligencja w sterowaniu i zarządzaniu produkcją (PG_00059488), W, L, C, ZiIP, sem. 1, stacjonarne II- st., letni 2023/2024
e-Learning Courses -
Imidazoacridinone C-1311 induces both autophagy and senescence in human lung cancer A549 cells
PublicationNiedrobnokomórkowy rak płuc (ang. NSCLC, non-small cell lung cancer), stanowiący blisko 80-87% wszystkich przypadków, jest najczęściej występującą formą raka płuc. Skuteczność dotychczas stosowanych chemoterapeutyków w stosunku do tej formy raka jest bardzo ograniczona dlatego poszukuje się nowych związków o lepszych właściwościach leczniczych. Imidazoakrydon C-1311 wykazuje wysoką aktywność cytotoksyczną wobec komórek niedrobnokomórkowego...
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B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma - Male, 70 - Tissue image [7040247104945081]
Open Research DataThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: VS200 Olympus slide scanner (20x magnification) and saved to DICOM format.
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High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [5040730028008421]
Open Research DataThis is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [5040730028007661]
Open Research DataThis is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [504073002800381]
Open Research DataThis is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [5040730028008041]
Open Research DataThis is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [5040730028009161]
Open Research DataThis is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [504073002800431]
Open Research DataThis is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [5040730028005641]
Open Research DataThis is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [5040730028003381]
Open Research DataThis is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [5040730028003631]
Open Research DataThis is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.