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Search results for: DNA MISMATCH REPAIR
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Optimising DNA binding to carbon nanotubes by non-covalent methods
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Evaluating experimental molecular physics studies of radiation damage in DNA*
PublicationThe field of Atomic and Molecular Physics (AMP) is a mature field exploring the spectroscopy, excitation, ionisation of atoms and molecules in all three phases. Understanding of the spectroscopy and collisional dynamics of AMP has been fundamental to the development and application of quantum mechanics and is applied across a broad range of disparate disciplines including atmospheric sciences, astrochemistry, combustion and environmental...
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Intercalation of imidazoacridinones to DNA and its relevance to cytotoxicand antitumor activity
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Evolutionary algorithm and decisional DNA for multiple travelling salesman problem
PublicationIn the real world, it is common to face optimization problems that have two or more objectives that must be optimized at the same time, that are typically explained in different units, and are in conflict with one another. This paper presents a hybrid structure that combines set of experience knowledge structures (SOEKS) and evolutionary algorithms, NSGA-II (Non-dominated Sorting Genetic Algorithm II), to solve multiple optimization...
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Modelling charge transfer processes in C2+ -tetrahydrofuran collision for ion-induced radiation damage in DNA building blocks
PublicationInvestigations of collision-induced processes involving carbon ions and molecules of biological interest in particular DNA building blocks, are crucial to model the effect of radiation on cells in order to improve medical treatments for cancer therapy. Using carbon ions appears to be one of the most efficient ways to increase biological effectiveness to damage cancerous cells by irradiating deep-seated tumors. Therefore, interest...
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Effects of metallic silver island films on resonance energy transfer between N,N´-(dipropyl)-tetramethylindocarbocyanine (Cy3)- and N,N´-(dipro- pyl)-tetramethylindodicarbocyanine ( Cy5 )-labeled DNA.
PublicationZbadano nową metodę zwiększania odległości rezonansowego przekazywania energii poprzez umieszczanie znakowanych donorami i akceptorami oligomerów DNA pomiędzy dwoma płytkami pokrytymi nanocząsteczkami metalicznego srebra.
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Induced Pluripotent Stem Cell (iPSC)–Derived Extracellular Vesicles Are Safer and More Effective for Cardiac Repair Than iPSCs
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Investigation of abdomen surface deformation due to life excitation: implications for implant selection and orientation in laparoscopic ventral hernia repair
PublicationVentral hernia is a common medical problem. Statistically there are around 10% recurrences of the sickness. The authors' former investigation proved edges of the hernia orifice displacements to be one of the factors causing recurrence. Thus, experimental investigation of the abdomen surface deformation due to some normal activities of people is studied.The extreme strains, their localization and directions are identified. The acquired...
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Selected symmetrically substituted carbazoles: Investigation of anticancer activity and mechanisms of action at the cellular and molecular levels
PublicationDNA topoisomerases play a critical role as essential enzymes in controlling alterations in the topology of DNA. They achieve this by orchestrating the coordinated process of breaking and rejoining DNA strands, which is crucial for maintaining the proper structure of DNA during regular cellular development. The search for and development of new potential anticancer drugs is a challenging yet immensely important area of research...
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Granie nie tylko na murawie! Zostań Lewandowskim pipety i termocyklera. Synergia nowoczesnych metod analitycznych opartych o wykrywanie DNA z nowymi formami nauczania (grywalizacja).
PublicationKOnkurs Innowacji Dydaktyznych PG: "Granie nie tylko na murawie! Zostań Lewandowskim pipety i termocyklera. Synergia nowoczesnych metod analitycznych opartych o wykrywanie DNA z nowymi formami nauczania (grywalizacja)."
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Detection of Helicobacter rodentium-like DNA in the liver tissue of patients with chronic liver diseases by polymerase chain reaction–denaturing gradient gel electrophoresis and DNA sequence analysis
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Molecular dynamics simulations reveal the balance of forces governing the formation of a guanine tetrad—a common structural unit of G-quadruplex DNA
PublicationG-quadruplexes (G4) are nucleic acid conformations of guanine-rich sequences, in which guanines are arranged in the square-planar G-tetrads, stacked on one another. G4 motifs form in vivo and are implicated in regulation of such processes as gene expression and chromosome maintenance. The structure and stability of various G4 topologies were determined experimentally; however, the driving forces for their formation are not fully...
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Orthodontic characteristics of maxillary arch deficiency in 5-year-old patientsundergoing unilateral cleft lip and palate repair with and withoutearly gingivoplasty
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Induced circularly polarized luminescence for revealing DNA binding with fluorescent dyes
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Regulation of the switch from early to late bacteriophage λ DNA replication
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Diagnosis of Brain Tumors Through Global Specific DNA Methylation Analysis
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Molecular Diagnostics of Brain Tumours by Measuring the 5-Methylcytosine Level in Their DNA
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P04.06 Temozolomide influence on global DNA methylation in glioblastoma cell lines
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Effects of Base π-Stacking on Damage to DNA by Low-Energy Electrons
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High Concentrations of Excised Oxidative DNA Lesions in Human Cerebrospinal Fluid
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Severe oxidatively damaged DNA after cisplatin treatment of cancer patients
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Oxidative DNA damage in cancer patients: a cause or a consequence of the disease development?
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Vitamin C enhances substantially formation of 5-hydroxymethyluracil in cellular DNA
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Central carbon metabolism influences fidelity of DNA replication in Escherichia coli
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Molecular differences in mitochondrial DNA genomes of dogs with malignant mammary tumours
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Analysis of differences in the stability of proteins encoded in mitochondrial DNA of model organisms
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Mitochondrial DNA of Anisakis simplex S.S. as a Potential Tool for Differentiating Populations
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Novel Method of Identifying DNA Methylation Fingerprint of Acute Myeloid Leukaemia
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Obliczenia numeryczne konstrukcji dna jachtu podczas wejścia na mieliznę
PublicationPozytywne zmiany w dostępie do żeglarstwa, które dokonały się w ostatnim dziesięcioleciu spowodowały wzrost liczby osób uprawiających ten sport. Przepisy, wg których projektowane są jachty nie stawiają żadnych wymagań wytrzymałości konstrukcji na wypadek kolizji jednostki z dnem. Z doświadczenia wiadomo, że wejście jachtu na piaszczystą mieliznę nie musi powodować uszkodzeń, jednak kolizja z podwodną skałą w szkierach szwedzkich...
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Direct cloning of heavy metal resistance genes from metagenomic DNA
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Relationship between selected DNA polymorphisms and coronary artery disease complications
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Cross section calculations for electron scattering from DNA and RNA bases.
PublicationPoliczono różniczkowy i scałkowany przekrój czynny na rozproszenie sprężyste elektronów (w przybliżeniu atomów niezależnych) na uracylu, cytozynie, guaninie, adeninie i tyminie w zakresie energii od 50-4000 eV. W przybliżeniu modelu BEB policzono również przekroje czynne na jonizację tych molekuł.
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Trójwymiarowe obrazowanie dna morskiego ze szczególnym uwzględnieniem wód płytkich
PublicationW ostatnim dziesięcioleciu nabrały znaczenia obserwacje szerokokątne (ang. swath scan) przy pomocy sonarów bocznych i sonarów wielowiązkowych. Wynikiem pomiarów dokonywanych przy pomocy sonarów wielowiązkowych jest jednak duża liczba danych geoprzestrzennych o precyzyjnie określonej referencji geograficznej, charakteryzujących się zróżnicowaną dynamiką i posiadających zróżnicowaną rozdzielczość. Stwarza to problemy w procesie...
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Przetwarzanie i analiza obrazów sonarowych powierzchni dna basenu portowego
PublicationW artykule przedstawiono problemy związane z poszukiwaniem obiektów zalegających na dnie basenu portowego.
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Representing and Managing Experiential Knowledge with Decisional DNA and its Drimos® Extension
PublicationThe Semantic Web concept is proposing a future concept of the WorldWideWeb (WWW) where both humans and man-made systems are able to interconnect and exchange knowledge. One of the challenges of Semantic Web is smart and trusted accommodation of knowledge in artificial systems so it can be unified, enhanced, reused, shared, communicated and distributed with added aptitude. Our research represents an important component of addressing...
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DNA Computing and Molecular Programming (International Meeting on DNA Computing and Molecular Programming)
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Why do G-quadruplexes dimerize through the 5’-ends? Driving forces for G4 DNA dimerization examined in atomic detail
PublicationG-quadruplexes (G4) are secondary structures formed by guanine-rich nucleic acid sequences and shown to exist in living cells where they participate in regulation of gene expression and chromosome maintenance. G-quadruplexes with solvent-exposed guanine tetrads show the tendency to associate together through cofacial stacking, which may be important for packaging of G4-forming sequences and allows for the design of higher-order...
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CERVIX UTERI, Exocervix - Female, 46 - Cell image [4140730008823071]
Open Research DataThis is the histopathological image of CERVIX UTERI cell sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Confirmative electric DNA array-based test for food poisoning Bacillus cereus
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Theoretical Study of Damage to DNA by 0.2−1.5 eV Electrons Attached to Cytosine
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Diet is Not Responsible for the Presence of Several Oxidatively Damaged DNA Lesions in Mouse Urine
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Selenium Supplementation Reduced Oxidative DNA Damage in Adnexectomized BRCA1 Mutations Carriers
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Comparison of Oxidative Stress/DNA Damage in Semen and Blood of Fertile and Infertile Men
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Comparative Analysis of CpG Sites and Islands Distributed in Mitochondrial DNA of Model Organisms
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Altered levels of circulating nuclear and mitochondrial DNA in patients with Papillary Thyroid Cancer
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Ancient mitochondrial DNA and the genetic history of Eurasian beaver (Castor fiber) in Europe
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Wpływ dodatku kwasu deoksyrybonukleinowego (DNA) na właściwości mechaniczne żeli żelatynowych
PublicationKwasy nukleinowe cieszą się coraz większym zainteresowaniem pod względem zastosowania ich w przemyśle farmaceutycznym, kosmetycznym oraz żywnościowym. Określono wpływ dodatku długo- i krótkołańcuchowych kwasów nukleinowych na właściwości mechaniczne żeli żelatynowych. Badania wykazały występowanie specyficznych interakcji pomiędzy żelatyną a kwasami nukleinowymi oraz pozwoliły na ocenę wpływu tych oddziaływań na twardość, kohezyjność,...
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C-1311 (Symadex), a potential anti-cancer drug, intercalates into DNA between A and G moieties. NMR-derived and MD-refined stereostructure of the d(GAGGCCTC) 2 :C-1311 complex
PublicationImidazoacridinone C-1311 (Symadex®) is an antitumor agent which has been recommended for Phase II clinical trials a few years ago. Previously, it was shown experimentally that during the initial stage of its action C-1311 forms stable intercalation complexes with DNA duplexes. Herein, a NMR-derived stereostructure of d(GAGGCCTC)2:C-1311 complex was reported. The ligand was found locating itself between A and G moieties, forming...
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Orthodontic characteristics of maxillary arch deficiency in 5-year-old patients undergoing unilateral cleft lip and palate repair with and without early gingivoplasty
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Late Aortic Remodeling after Endovascular Repair of Complicated Type B Aortic Dissection—TEVAR Protects Only the Covered Segment of Thoracic Aorta
PublicationIntroduction: TEVAR is the preferred way of treatment of complicated type B aortic dissection. The purpose of the study was to assess the impact of TEVAR on aortic remodelling in the thoracic and abdominal segment in long-term follow-up. Methods: 23 patients with complicated type B aortic dissection were treated by TEVAR in years 2004-2012 in our Department. Aortic remodelling was rated based on preoperative and final follow-up...