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Extracellular Matrix Proteins Expression Profiling in Chemoresistant Variants of the A2780 Ovarian Cancer Cell Line
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Positive electrostatic therapy of metastatic tumors: selective induction of apoptosis in cancer cells by pure charges
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Selective inhibition of cancer cells' proliferation by compounds included in extracts from Baltic Sea cyanobacteria
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The variant allele of the rs188140481 polymorphism confers a moderate increase in the risk of prostate cancer in Polish men
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Discrimination of normal oral mucosa from oral cancer by mass spectrometry imaging of proteins and lipids
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Sulforaphane, a cruciferous vegetable-derived isothiocyanate, inhibits protein synthesis in human prostate cancer cells
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EP-1817: Radiotherapy-related changes in serum proteome patterns of head and neck cancer patients
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p53 Gene status in relation to ex vivo chemosensitivity of non-small cell lung cancer
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Polymer-free cubosomes for simultaneous bioimaging and photodynamic action of photosensitizers in melanoma skin cancer cells
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Biological effects in photodynamic treatment combined with electropermeabilization in wild and drug resistant breast cancer cells
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Cardioprotection during cancer chemotherapy with the use of natural antioxidants: review of literature and results of own studies
PublicationDoniesienie poświęcone jest wykorzystaniu naturalnych antyoksydantów w ochronie mięśnia sercowego przed toksycznym działaniem antracyklin wykorzystywanych w leczeniu nowotworów. Pokazane zostało działanie ochronne kilku związków oraz zwierających je składników żywności w tym buraka czerwonego, który był przedmiotem badań własnych.
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Molecular modeling and evaluation of novel dibenzopyrrole derivatives as telomerase inhibitors and potential drug for cancer therapy
PublicationDuring previous years, many studies on synthesis, as well as on anti-tumor, anti-inflammatory and anti-bacterial activities of the pyrazole derivatives have been described. Certain pyrazole derivatives exhibit important pharmacological activities and have proved to be useful template in drug research. Considering importance of pyrazole template, in current work the series of novel inhibitors were designed by replacing central...
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Combinatory Treatment with miR-7-5p and Drug-Loaded Cubosomes Effectively Impairs Cancer Cells
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Global wealth disparities drive adherence to COVID-safe pathways in head and neck cancer surgery
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Telomere Length and Risk of Major Adverse Cardiac Events and Cancer in Obstructive Sleep Apnea Patients
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Tuning of the Anti-Breast Cancer Activity of Betulinic Acid via Its Conversion to Ionic Liquids
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The Prognostic Value of PI-RADS Score in CyberKnife Ultra-Hypofractionated Radiotherapy for Localized Prostate Cancer
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Molecular mechanism(s) of regulation(s) of c-MET/HGF signaling in head and neck cancer
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Poly(amidoamine) Dendrimer/Camptothecin Complex: From Synthesis to In Vitro Cancer Cell Line Studies
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GC-MS-based untargeted metabolomics of plasma and urine to evaluate metabolic changes in prostate cancer
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Comparison of RP-HPLC columns used for determination of nucleoside metabolic patterns in urine of cancer patients
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A novel green one-step synthesis of gold nanoparticles using crocin and their anti-cancer activities
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Altered Expression of ESR1, ESR2, PELP1 and c-SRC Genes Is Associated with Ovarian Cancer Manifestation
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Serum levels of IL-6, IL-8 and CRP as prognostic factors in epithelial ovarian cancer
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Bridging challenges of clinical decision support systems with a semantic approach. A case study on breast cancer
PublicationThe integration of Clinical Decision Support Systems (CDSS) in nowadays clinical environments has not been fully achieved yet. Although numerous approaches and technologies have been proposed since 1960, there are still open gaps that need to be bridged. In this work we present advances from the established state of the art, overcoming some of the most notorious reported difficulties in: (i) automating CDSS, (ii) clinical workflow...
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Role of size scale of ZnO nanoparticles and microparticles on toxicity toward bacteria and osteoblast cancer cells
PublicationThe specific role of size scale, surface capping, and aspect ratio of zinc oxide (ZnO) particles on toxicity toward prokaryotic and eukaryotic cells was investigated. ZnO nano and microparticles of controlled size and mor- phology were synthesized by wet chemical methods. Cytotoxicity toward mammalian cells was studied using a human osteoblast cancer cell line and antibacterial activity using Gram-negative bacteria (Escherichia...
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Natural Products Counteracting Cardiotoxicity during Cancer Chemotherapy: The Special Case of Doxorubicin, a Comprehensive Review
PublicationCardiotoxicity is a frequent undesirable phenomenon observed during oncological treatment that limits the therapeutic dose of antitumor drugs and thus may decrease the effec-‐‑ tiveness of cancer eradication. Almost all antitumor drugs exhibit toxic properties towards cardiac muscle. One of the underlying causes of cardiotoxicity is stimulation of oxidative...
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Anticancer Imidazoacridinone C-1311 is Effective in Androgen-Dependent and Androgen-Independent Prostate Cancer Cells
PublicationAndrogen receptor (AR) plays a crutial role in prostate cancer (PCa) development and metastasis. Here, we reported potent anti-PCa activity of a small molecule imidazoacridinone C-1311. In AR-positive PCa cells, C-1311 was found to inhibit the transcriptional activity of AR uncovering a novel mechanism that may be relevant for its anticancer effect. Mechanistically, C-1311 decreased AR binding to prostate-specific antigen (PSA)...
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Imidazoacridinone C-1311 induces both autophagy and senescence in human lung cancer A549 cells
PublicationNiedrobnokomórkowy rak płuc (ang. NSCLC, non-small cell lung cancer), stanowiący blisko 80-87% wszystkich przypadków, jest najczęściej występującą formą raka płuc. Skuteczność dotychczas stosowanych chemoterapeutyków w stosunku do tej formy raka jest bardzo ograniczona dlatego poszukuje się nowych związków o lepszych właściwościach leczniczych. Imidazoakrydon C-1311 wykazuje wysoką aktywność cytotoksyczną wobec komórek niedrobnokomórkowego...
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Cytokine IL6, but not IL-1β, TNF-α and NF-κB is increased in paediatric cancer patients
PublicationCytokines are responsible for maintaining homeostasis as cell growth, differentiation, migration and apoptosis mediators. They play a pivotal role in immune responses to inflammatory reactions. In oncological diseases, the cross-talk between cells of the immunological system and cells of the tumour microenvironment is led by cytokines. Also, the overproduction of cytokines may change the tumour microenvironment and stimulate tumour...
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Fatigue Bending of V-Notched Cold-Sprayed FeCoCrNiMn Coatings
PublicationCold-spray coatings were produced by FeCoCrNiMn high-entropy alloy powders deposited on carbon steel substrate. The coatings were realized at intermediate temperature and high pressure (at 1100 °C and 7 MPa). The coating microstructure was characterized by scanning electron microscopy and X-ray diffraction, revealing a very dense deposition and high flattening ratio of the splatted particles. This had a large influence on the...
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Reclaimed Rubber/Poly(ε‐caprolactone) Blends: Structure, Mechanical, and Thermal Properties
PublicationThe amount of elastomeric waste, especially from tires is constantly increasing on a global scale. The recycling of these residua should be considered a priority. Compounding the waste rubbers with other polymers can be an excellent alternative to reuse waste materials. This procedure requires solving the issue of the lack of compatibility between the waste rubber particles and other polymers. Simultaneously, there is a claim for...
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Room temperature synthesis of water-dispersible Ln 3+ :CeF 3 (Ln = Nd, Tb) nanoparticles with different morphology as bimodal probes for fluorescence and CT imaging
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Low-dose radiation accelerates aging of the T-cell receptor repertoire in CBA/Ca mice
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Global variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries
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Cytotoxicity of anthraquinone derivatives (Compound 1-9) towards H226 cancer cell
Open Research DataThis study presents absorbance values of formazan product (converted from MTT) which corresponds to the cytotoxicity of anthraquinone derivatives (Compound 1-9) towards H226 cancer cells.
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Cytotoxicity of anthraquinone derivatives (Compound 1-9) towards A549 cancer cells
Open Research DataThis study presents absorbance values of formazan product (converted from MTT) which corresponds to the cytotoxicity of anthraquinone derivatives (Compound 1-9) towards A549 cancer cells.
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Cytotoxicity of anthraquinone derivatives (Compound 1-9) towards H460 cancer cell
Open Research DataThis study presents absorbance values of formazan product (converted from MTT) which corresponds to the cytotoxicity of anthraquinone derivatives (Compound 1-9) towards H460 cancer cells.
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Influence of microwave treatment conditions of GTR on physico-mechanical and structural properties of NBR/NR/GTR composites
PublicationThe increasing amount of tires used in the industry induces the researchers to find alternatives to the recycling of the end-of-life tires. Several alternatives in order to application of ground tire rubber GTR include their incorporation as a filler in composites. The main issue in this approach is the lack of compatibility between GTR and polymer matrix. In order to solve this problem the devulcanization by microwaves has been...
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Debonding of coin-shaped osseointegrated implants: Coupling of experimental and numerical approaches
PublicationWhile cementless implants are now widely used clinically, implant debonding still occur and is difficult to anticipate. Assessing the biomechanical strength of the bone–implant interface can help improving the understanding of osseointegration phenomena and thus preventing surgical failures. A dedicated and standardized implant model was considered. The samples were tested using a mode III cleavage device to assess the mechanical...
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CERVIX UTERI, Cervical canal - Female, 45 - Tissue image [5270730023443461]
Open Research DataThis is the histopathological image of CERVIX UTERI tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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CERVIX UTERI, Cervical canal - Female, 71 - Tissue image [6170730026738691]
Open Research DataThis is the histopathological image of CERVIX UTERI tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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CERVIX UTERI, Cervical canal - Female, 33 - Tissue image [9160729581051331]
Open Research DataThis is the histopathological image of CERVIX UTERI tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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CERVIX UTERI, Cervical canal - Female, 57 - Tissue image [3220630024676291]
Open Research DataThis is the histopathological image of CERVIX UTERI tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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CERVIX UTERI, Cervical canal - Female, 48 - Tissue image [10080730015788991]
Open Research DataThis is the histopathological image of CERVIX UTERI tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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CERVIX UTERI, Cervical canal - Female, 29 - Tissue image [9220729551207221]
Open Research DataThis is the histopathological image of CERVIX UTERI tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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CERVIX UTERI, Cervical canal - Female, 45 - Tissue image [5270730023443521]
Open Research DataThis is the histopathological image of CERVIX UTERI tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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CERVIX UTERI, Cervical canal - Female, 50 - Tissue image [5130730017406841]
Open Research DataThis is the histopathological image of CERVIX UTERI tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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CERVIX UTERI, Cervical canal - Female, 45 - Tissue image [5270730023451691]
Open Research DataThis is the histopathological image of CERVIX UTERI tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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CERVIX UTERI, Cervical canal - Female, 83 - Tissue image [12050630013035151]
Open Research DataThis is the histopathological image of CERVIX UTERI tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.