Search results for: LEVORIN

• The structure of levorin A3, a minor component of levorin complex

  Publication

  • J. Pawlak
  • P. Sowiński
  • T. Bieszczad
  • E. Borowski

  - Year 2005

  Budowa chemiczna składnika kompleksu leworyn, leworyny A3, została ustalona na podstawie analizy z wykorzystaniem metod spektroskopowych UV, MS i NMR metoksykarbonylometyloamido pochodnej leworyny A3. Widmo UV wskazało obecność chromoforu heptaenowego. Ciężar cząsteczkowy leworyny A3 ustalono jako 1110 j.m. za pomocą spektrometrii masowej z wykorzystaniem techniki FAB, co po uwzględnieniu uwarunkowań biogenetycznych pozwoliło wydedukować...

• The structure, including stereochemistry, of levorin A1

  Publication

  • K. Szwarc-Karabyka
  • P. Szczeblewski
  • P. Sowiński
  • E. Borowski
  • J. Pawlak

  - MAGNETIC RESONANCE IN CHEMISTRY - Year 2015

  The constitution and stereostructure of levorin A1 1, an aromatic heptaeneantifungal antibiotic, was established on the basis of NMR studies, which contained DQFCOSY,ROESY, HSQC and HMBC experiments. Mycosamine moiety was used as an internalchiral probe to determine the absolute configuration of levorin A1 stereogenic centers: 13S,15R, 17S, 18R, 19S, 21R. The relative configuration of the remaining stereogenic centers wasassigned...

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• The complete stereochemistry of the antibiotic candicidin A3 (syn. ascosin A3, levorin A3)

  Publication

  • J. Borzyszkowska-Bukowska
  • P. Szczeblewski
  • A. Konkol
  • J. Grynda
  • K. Szwarc-Karabyka
  • T. Laskowski

  - NATURAL PRODUCT RESEARCH - Year 2019

  Herein, the stereostructure of the aromatic heptaene macrolide (AHM) antifungal antibiotic candicidin A3 (syn. ascosin A3, levorin A3) has been established upon the 2D NMR studies, consisting of DQF-COSY, TOCSY, ROESY, HSQC and HMBC experiments, as well as upon extensive molecular dynamics simulations. The geometry of the heptaenic chromophore was defined as: (22E, 24E, 26Z, 28Z, 30E, 32E, 34E). The previously unreported absolute...

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• Analytical studies on ascosin, candicidin and levorin multicomponent antifungal antibiotic complexes. The stereostructure of ascosin A2

  Publication

  • P. Szczeblewski
  • T. Laskowski
  • B. Kubacki
  • M. Dziergowska
  • M. Liczmańska
  • J. Grynda
  • P. Kubica
  • A. Kot-Wasik
  • E. Borowski

  - Scientific Reports - Year 2017

  In the class of polyene macrolides, there is a subgroup of aromatic heptaenes, which exhibit the highest antifungal activity within this type of antibiotics. Yet, due to their complex nature, aromatic heptaenes were not extensively studied and their potential as drugs is currently underexploited. Moreover, there are many inconsistencies in the literature regarding the composition and the structures of the individual components...

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