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An integrated DNA and RNA variant detector identifies a highly conserved three base exon in the MAP4K5 kinase locus
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Gene Expression and Activity Profiling Reveal a Significant Contribution of Exo‐Phosphotransferases to the Extracellular Nucleotides Metabolism in HUVEC Endothelial Cells
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Dni informacyjne – Fundusze norweskie i EOG
EventsCelem spotkania jest przekazanie uczestnikom informacji dotyczących najbliższych konkursów organizowanych przez NCBiR i finansowanych w ramach funduszy norweskich i EOG. Organizator – NCBiR.
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Białka prokariotycznego systemu MMR: rola oraz interakcje
PublicationUszkodzenia komórkowego DNA w postaci błędnie sparowanych lub niesparowanych zasad azotowych są wynikiem niewłaściwie zachodzących procesów metabolizmu DNA, takich jak replikacja, rekombinacja oraz naprawa DNA. Utrwalenie tego rodzaju zmian prowadzi do powstania mutacji. System MMR (ang. DNA mismatch repair) usuwa te uszkodzenia przyczyniając się do zwiększenia wierności replikacji DNA oraz utrzymania stabilności genomu komórki....
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Unraveling the Interplay between DNA and Proteins: A Computational Exploration of Sequence and Structure-Specific Recognition Mechanisms
PublicationMy PhD dissertation focused on DNA-protein interactions and the recognition of specific DNA sequences and structures. I discovered that acidic amino acid residues (Asp/Glu) play a crucial role by exhibiting a preference for cytosine. Their contribution to binding affinity depends on nearby cytosines, balancing electrostatic repulsion with specific interactions. Acidic residues act as negative selectors, discouraging non-cytosine...
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Visually validated semi-automatic high-frequency oscillation detection aides the delineation of epileptogenic regions during intra-operative electrocorticography
PublicationOBJECTIVE: To test the utility of a novel semi-automated method for detecting, validating, and quantifying high-frequency oscillations (HFOs): ripples (80-200 Hz) and fast ripples (200-600 Hz) in intra-operative electrocorticography (ECoG) recordings. METHODS: Sixteen adult patients with temporal lobe epilepsy (TLE) had intra-operative ECoG recordings at the time of resection. The computer-annotated ECoG recordings were visually...
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Genetic features of clinical Pseudomonas aeruginosa strains
PublicationW grupie 62 izolatów klinicznych sprawdzono obecność 6 wybranych czynnikow wirulencji. We wcześniejszych badaniach z wykorzystaniem techniki ERIC - PCR wykazano, że w analizowanej grupie 49 (79%) to szczepy, o dużum podobieństwie genetycznym (ponad 62%), każdy z pozostałych 13 izolatów zaliczono do osobnego genotypu, o zdecydownie niższym stopniu pokrewieństwa. W przypadku wszystkich 49 szczepów z pierwszej grupy stwierdzono obecność...
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Silver nanoparticles induce premutagenic DNA oxidation that can be prevented by phytochemicals from Gentiana asclepiadea
PublicationAmong nanomaterials, silver nanoparticles (AgNPs) have the broadest and most commercial applications due to their antibacterial properties, highlighting the need for exploring their potential toxicity and underlying mechanisms of action. Our main aim was to investigate whether AgNPs exert toxicity by inducing oxidative damage to DNA in human kidney HEK 293 cells. In addition, we tested whether this damage could be counteracted...
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Brain-computer interaction based on EEG signal and gaze-tracking information = Analiza interackji mózg-komputer wykorzystująca sygnał EEg i informacje z systemu śledzenia punktu fiksacji wzroku
PublicationThe article presents an attempt to integrate EEG signal analysis with information about human visual activities, i.e. gaze fixation point. The results from gaze-tracking-based measurement were combined with the standard EEG analysis. A search for correlation between the brain activity and the region of the screen observed by the user was performed. The preliminary stage of the study consists in electrooculography (EOG) signal processing....
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The crystal structure of (1RS,4RS,5RS,6SR)-5-cyano-5-nitro-6-phenyl-bicyclo[2.2.1]hept-2-ene
PublicationStructure of nitronorbornene derivative C14H12N2O2 synthesized in the reaction of cyclopentadiene with E-2-phenyl-1-cyano-1-nitroethene was determined by single crystal X-ray diffraction analysis. It was found that in analyzed molecule the nitro group is in endo-position whereas phenyl group have exo-ori-entation.